The study found that vitamin D supplementation was less effective in obesity

A new study has confirmed that vitamin D supplementation is less effective in obesity, revealing a biological mechanism behind the phenomenon The study was published in Journal of bone and mineral research This study found that the enzyme responsible for transforming vitamin D into 25 hydroxyvitamin D (ossifying diol) in the liver of obese mice was low, and 25 hydroxyvitamin D was the main form of vitamin D in the blood Therefore, for obese patients, the treatment of vitamin D deficiency with ossifying diol should be more effective than other forms of vitamin D Dr Jeffrey Roizen, lead author of the study and director of children's Hospital in Philadelphia, said: "the level of ossifying diol in the blood of obese patients is usually very low, which has been attributed to the binding of vitamin D by fat cells Now we propose a second, more biologically significant mechanism: Obesity reduces the liver's ability to convert vitamin D into 25 hydroxyvitamin D "Our findings suggest that obesity affects this early activation of vitamin D, which suggests that the clinical effects of obesity on the liver have important systemic effects on bone and mineral metabolism," said Dr Jeffrey Roizen In addition, in the past, we always thought that too low vitamin D content led to obesity Our work shows that in fact, disease or pathological state (such as obesity) led to low vitamin D content "