The study reveals the developmental space-time specificity of cell esoteric variation

Through real-time imaging and single-cell quantitative analysis of the embryo development of the beautiful reclusive rod nematode, the team found that the variation of normal embryonic cell positioning has a high degree of certainty and consistency over time, regulated by internal and external mechanisms. The results were published in the journal Cell Reports.
embryo is a highly repeatable and robust process that enables it to maintain relative stability in a complex environment. Previously, much of the research in developmental biology focused on explaining the commonality of molecular and cellular behavior, with less attention paid to its variability. There is growing evidence that at the molecular and cellular levels, the development process exhibits a considerable degree of inherent variability, and systematic analysis of the source, nature and significance of developmental variability will provide an important perspective for understanding the establishment and maintenance of developmental reproducory.
Duchoval team systematically quantified the variability of the behavior of cell positioning in embryos, and found that the degree of variation was influenced by the developmental characteristics of cells, including the origin of cell development, embryonic region positioning, intercellular contact, symmetrical scheduling, etc. The degree of variation changes with a high degree of consistent dynamics over time, and cell fate decisions and cell-connected molecules help reduce variability. This study helps to understand the cellular basis of developmental reproducity and expands the understanding of cell esopreetic mutation development regulation. (Source: Science Network Li Chenyang Liu