The study reveals the scientific principles of the "Wall Crash Period"

, swimmers and cyclists are familiar with the phenomenon of "wall-crashing". Recently, researchers reported
the physiological basis of this phenomenon in the Journal of Technology. The study also found that training is not the only way to improve endurance, and that using a small molecule to stimulate a training activation path can also achieve the goal.
"When your brain can't get enough glucose, there's a 'wall-knocking period', which means you can't keep moving," he says. Previously we thought we could improve people's aerobic endurance through training. Co-author Ronald Evans, a researcher at the Shack Institute for Biomedical Research in the United States, said.
previously discovered by the Evans team that a transcription factor called PPAR can also activate path path paths that are activated when an athlete increases endurance through training. The researchers demonstrated that this metabolic change depends on both PPAR and molecular activation.
in the first experiment, they knocked out PPAR in the muscles of mice and studied the effect. The researchers asked the mice to run on a treadmill and found that the gene, which is usually triggered by exercise, was not triggered. This shows that PPAR plays an important role in motion.
, the researchers used a small molecular drug to activate PPAR in sedentented mice. They found that the drug not only increased fat oxidation in muscle, but also inhibited hypoglycemia or loss of blood sugar in the brain. The result was that even without exercise to train endurance, the mice were able to increase the length of running before the "wall-crash period" -- from 160 minutes to 270 minutes.
results will provide athletes with new ways to improve endurance, and also give patients with heart, lung, type 2 diabetes or other health problems hope to use the drug for aerobic exercise benefits, the researchers said. And this small molecule drug may be used to increase fat burning in obese or type 2 diabetics and improve patient health before and after surgery