The surface genetic diet, which resists environmental pollution, | Clinical Epigenetics

Title: Prenatal epigenetics diets play role role againstst environmental pollution
Journal:
Shizhao Li, Min Chen, Yuanyuan Li and Trygve O. Tollefsbol
Published time: 2019/03/16
DOI:
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Nutrition early although not able to change DNA, but it can significantly affect development by adjusting gene expression. A team of researchers from the University of Alabama at Birmingham has found that an "ontological genetic diet" helps prevent the adverse effects of exposure to environmental pollution in the womb and after birth, according to a recent review published in
.early dietary nutrition has a significant impact on the fate of individual development and disease prevention. For example, the presence or absence of bee king pulp can determine whether female bee larvae will develop into bee king (there is bee king pulp) or not able to reproduce the worker bee (no bee king pulp). In a recent review published in
, the authors report on the important role of specific diets in preventing environmentally induced or presupfadied genetic diseases, which are achieved primarily by regulating gene expression.is an important complement to the central law of molecular biology and reflects the interaction of the genome with its environment. The change in the observational genetics affects the expression of the gene, but does not make any changes to the DNA sequence. The ornamental genome refers to all the surface genetic modification of the genome, of which DNA methylation and histogene modification are the most important.
mammalian esogens undergo two major elimination and reconstruction cycles, including the stage of mating and the period of early embryogenes, during which the ostructum genome is vulnerable to environmental factors (see figure below).Environmental pollution, including environmental air pollution (e.g. particulate matter, smoke, polycyclic aromatic hydrocarbons, etc.), hormone-destroying chemicals (e.g. BPA, agro-lyn, persistent organic pollutants, etc.), and heavy metals (e.g. arsenic, cadmium, lead, etc.). They can have a serious impact on human health, especially on the early life of fetuses and infants.Tollefsbol's lab coined the term epigenetic diet in 2011. It refers to a class of biologically active dietary compounds such as isothion cyanate in western orchids, dye wood flavonoids in soybeans, resveratrol in red grapes, and other common foods. They have all been shown to alter the lookout genome to produce healthy results. An oscic genetic diet can inhibit tumor progression by regulating osclo genetic modification enzymes such as DNA methyl transferase and histogenetic deacetylase, as well as certain non-coding RNA.we finished our recent article, we reviewed some recent advanced research.
For example, BPA is a public health concern for hormone-destroying chemicals, and by dietary supplementation of methyl supplements (e.g. vitamin B12, folic acid, choline, etc.) and isoflavone dye flavonoids, the obidophenol A-induced obidogenic disorders can be reversed. B vitamins may prevent DNA methylation losses caused by air pollution. Dietary folic acid supplements have been shown to prevent adverse reactions caused by heavy metals.
we believe that the surface genetic reagents may be used to counteract the surface genomic defects caused by environmental pollution. In the article, we draw attention to environmental toxins and chemicals that may be present in certain foods, such as pesticides in fruits (e.g. strawberries) and green leafy vegetables (e.g. spinach), biphenol A in plastic containers for food and beverages, bihyoxins in fatty foods, polycyclic aromatic hydrocarbons when meat is roasted or smoked at high temperatures, and mercury in certain seafood (e.g. mackerel and swordfish). These exposures, especially during early development, can have far-reaching effects on children's later health/disease consequences through pre-existing genetic mechanisms.
genetic modification has become an attractive therapeutic target because of its reversible nature.
(Source: Science.com)