The switching mechanism of the TRIC ion channel.

TRIC ion channels play an important physiological function in the human body, and their absence or mutation is closely related to some diseases.
TRIC ion channel has two sub-types, TRIC-A and TRIC-B.
TRIC-A channel is a potential drug target for the treatment of malignant hypertension;
therefore, the study of the three-dimensional structure-function of the TRIC ion channel will be of great significance for understanding the calcium ion signals in tissues such as myocardial cells and skeletal muscle cells.
bioinscerology has found that TRIC ion channels exist not only in mammals, but also in primary nuclear organisms.
Chen Aerospace Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences completed the high-resolution three-dimensional structure and related functional analysis of TRIC ion channels from ancient bacteria and bacteria, and proposed the switching mechanism of TRIC ion channels.
study was published May 19 in Nature Communications (DOI: 10.1038/ncomms15103).
, a member of the Chen Aerospace Research Group, staff member, Mao Yang, a graduate student, Li Delin, a doctoral student, and Qi Yuan of the Andrew Marks Research Group, were the co-authors of the paper.
this article is written by Chen Yuhang.
research has been funded by the Chinese Academy of Sciences' Strategic Pilot Project, the Ministry of Science and Technology's major research and development program and the National Natural Science Foundation of China.
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