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1-Benzyl-4-methylpiperidin-3-ol is a synthetic chemical compound that is commonly used in the pharmaceutical, cosmetics, and fragrance industries.
It has a distinctive odor and is often used as a fragrance ingredient in perfumes, soaps, and other personal care products.
The compound is also used in the production of some medications, including antidepressants and anti-inflammatory drugs.
There are several synthetic routes to 1-benzyl-4-methylpiperidin-3-ol, each with its own advantages and disadvantages.
The following are some of the most commonly used synthetic routes:
- Hydrogenation of N-benzylidene-N-methyl-piperidine
This route involves the reduction of N-benzylidene-N-methyl-piperidine using hydrogen gas in the presence of a catalyst such as palladium on barium sulfate.
The reduced product is then separated from the catalyst using a solvent such as ethyl acetate.
This route is commonly used in industry and is considered to be a reliable method for the production of 1-benzyl-4-methylpiperidin-3-ol.
- Reduction of N-benzyl-N-methylpiperidine-4-amine
This route involves the reduction of N-benzyl-N-methylpiperidine-4-amine using a reducing agent such as lithium aluminum hydride (LiAlH4) in the presence of a solvent such as tetrahydrofuran (THF).
The reduced product is then separated from the reducing agent using a solvent such as water.
This route is also commonly used in industry and is considered to be a reliable method for the production of 1-benzyl-4-methylpiperidin-3-ol.
- Reduction of N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylurea
This route involves the reduction of N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylurea using lithium aluminum hydride (LiAlH4) in the presence of a solvent such as THF.
The reduced product is then separated from the reducing agent using a solvent such as water.
This route is also commonly used in industry and is considered to be a reliable method for the production of 1-benzyl-4-methylpiperidin-3-ol.
- Reduction of N-(1-benzyl-4-methylpiperidin-3-yl)acetamide
This route involves the reduction of N-(1-benzyl-4-methylpiperidin-3-yl)acetamide using lithium aluminum hydride (LiAlH4) in the presence of a solvent such as THF.
The reduced product is then separated from the reducing agent using a solvent such as water.
This route is less commonly used in industry but has been reported to yield good results.
- Reduction of N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylamine
This route involves the reduction of N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylamine using a reducing agent such as ascorbic acid in the presence of a solvent such as water.
The reduced product is then separated from the reducing agent using a solvent such as ethyl acetate.
This route is less commonly used in industry but has been reported to yield good results.
In conclusion, there are several synthetic routes to 1
