The Synthetic Routes of 2-METHOXYISONICOTINAMIDE

2-Methoxyisonicotinamide, also known as 2-methoxy-5-isonicotinamide, is a chemical compound that is commonly used in the field of organic synthesis.
It is a versatile building block that can be used to synthesize a wide variety of compounds, including pharmaceuticals, agrochemicals, and materials.

There are several synthetic routes that can be used to synthesize 2-methoxyisonicotinamide, each with its own advantages and disadvantages.
In this article, we will discuss some of the most common synthetic routes used to synthesize 2-methoxyisonicotinamide.

One of the most common synthetic routes to 2-methoxyisonicotinamide involves the reaction of 2-methoxy-5-nitrobenzaldehyde with sodium cyanide.
This reaction involves the formation of a Grignard reagent, which is then treated with sodium hydroxide to generate the nitrosonium ion.
The nitrosonium ion then undergoes a nucleophilic substitution reaction with the 2-methoxy-5-nitrobenzaldehyde, forming 2-methoxyisonicotinamide.

Another synthetic route to 2-methoxyisonicotinamide involves the reaction of 2-methoxy-5-bromobenzoic acid with sodium hydroxide in the presence of a Lewis acid catalyst, such as aluminum chloride.
This reaction leads to the formation of 2-methoxyisonicotinamide via an intermediate oxime.

Yet another synthetic route to 2-methoxyisonicotinamide involves the reaction of 2-methoxy-5-nitrobenzaldehyde with ammonia in the presence of a Lewis acid catalyst, such as boron trifluoride.
This reaction leads to the formation of 2-methoxyisonicotinamide via an intermediate imine.

Regardless of the synthetic route used, it is important to handle 2-methoxyisonicotinamide with care, as it is a sensitive and unstable compound.
It is typically stored in a dry, cool, and well-ventilated area, and should be handled with gloves and eye protection.
In addition, it is important to use appropriate safety equipment, such as a fume hood, when working with 2-methoxyisonicotinamide to prevent exposure to potentially harmful vapors.

Overall, 2-methoxyisonicotinamide is a valuable building block in organic synthesis, and several synthetic routes are available for its synthesis.
These routes offer a variety of advantages and disadvantages, and the choice of route will depend on the specific application and desired product.
Regardless of the route used, it is important to handle 2-methoxyisonicotinamide with care, as it is a sensitive and unstable compound.