The Synthetic Routes of 2-Propenoic acid, 3-(5-nitro-1-cyclohexen-1-yl)-, (1R)-4-(diphenylaMino)-1-Methyl-4-oxo-2-butyn-1-yl ester, (2E)-

2-Propenoic acid, 3-(5-nitro-1-cyclohexen-1-yl)-, (1R)-4-(diphenylaMino)-1-Methyl-4-oxo-2-butyn-1-yl ester, (2E)-, also known as Aliskiren, is a synthetic chemical compound commonly used in the pharmaceutical industry as an anti-hypertensive drug.
The compound is synthesized using various chemical reactions and methods, and the choice of synthetic route depends on several factors, such as the availability of starting materials, the desired yield, and the cost of the synthesis.
In this article, we will discuss some of the most common synthetic routes of Aliskiren and their applications in the chemical industry.

One of the most common methods of synthesizing Aliskiren involves a sequence of reactions known as the "Scheme 1" synthetic route.
This route involves the synthesis of the starting material, 5-nitro-1-cyclohexene, which is then transformed into the desired product through a series of chemical reactions.
These reactions typically involve the use of reagents such as lithium aluminum hydride (LiAlH4) and hydrogen chloride (HCl) and are carried out in several steps.

Another synthetic route for Aliskiren is the "Scheme 2" synthetic route, which involves the synthesis of the starting material, dimethyl amino oxalate, followed by a series of chemical reactions.
This route typically involves the use of reagents such as sodium hydroxide (NaOH) and hydrochloric acid (HCl) and is also carried out in several steps.

Both of these synthetic routes have their own advantages and disadvantages, and the choice of route depends on the specific requirements of the synthesis.
For example, the Scheme 1 route typically requires the use of more expensive reagents and is more time-consuming, but may offer a higher yield of the desired product.
On the other hand, the Scheme 2 route may be less expensive and require less time, but may yield a lower amount of the desired product.

In addition to these synthetic routes, there are also other methods of synthesizing Aliskiren that have been developed in recent years.
One such method involves the use of microorganisms such as bacteria to produce the compound through biotechnological methods.
This method has the advantage of being more environmentally friendly and may offer a more sustainable source of the compound.
However, this method is still in the early stages of development and is not yet widely used in the industry.

In conclusion, the synthetic routes of Aliskiren, (2E)-2-Propenoic acid, 3-(5-nitro-1-cyclohexen-1-yl)-, (1R)-4-(diphenylaMino)-1-Methyl-4-oxo-2-butyn-1-yl ester, are many and varied, and the choice of route depends on several factors.
The use of biotechnological methods for the synthesis of the compound is an area of ongoing research and development.
Regardless of the chosen synthetic route, Aliskiren remains an important compound in the pharmaceutical industry for its use as an anti-hypertensive drug.