The Synthetic Routes of 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone(SALTDATA: FREE)

4-Bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone, also known as SALTDATA or FREE, is a synthetic compound with a wide range of potential applications in the chemical industry.
This compound has been the subject of much research in recent years due to its unique properties and promising potential.
The synthetic routes to this compound are numerous and varied, and the choice of route depends on several factors, including the desired yield, cost, and availability of starting materials.

One of the most common synthetic routes to 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone involves the reaction of 3-bromo-5-(1-pyrrolidinyl)-2H-pyrazine-2-carboxylic acid with sodium azide in the presence of a strong base such as sodium hydroxide.
This reaction results in the formation of the desired compound, along with the corresponding azide salt.
The azide salt can be subsequently transformed into the free base by treating it with a strong acid, such as hydrochloric acid.

Another synthetic route to 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone involves the reaction of 3-bromo-5-(1-pyrrolidinyl)-2H-pyrazine-2-carboxylic acid with excess of 2,4-dinitrophenyl compound, in the presence of a Lewis acid such as aluminium chloride.
This reaction results in the formation of the desired compound along with the corresponding 2,4-dinitrophenyl salt.
This salt can be subsequently transformed into the free base by treating it with a strong acid, such as hydrochloric acid.

A third synthetic route to 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone involves the reaction of 3-bromo-5-(1-pyrrolidinyl)-2H-pyrazine-2-carboxylic acid with excess of 2,5-dihydroxybenzene sulfonic acid in the presence of a Lewis acid such as aluminium chloride.
This reaction results in the formation of the desired compound along with the corresponding 2,5-dihydroxybenzene sulfonate salt.
This salt can be subsequently transformed into the free base by treating it with a strong acid, such as hydrochloric acid.

The choice of synthetic route depends on several factors, including the desired yield, cost, and availability of starting materials.
For example, the first route is relatively simple and can be performed using easily available reagents, but the yield may not be high.
The second route requires more specialized reagents and may be more expensive, but the yield can be higher.
The third route also may require more specialized reagents, but it is highly efficient, and the yield may be high.

Once the synthesis of 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone has been completed, the compound can be transformed into its desired form, such as a salt or a free base, depending on the desired application.
These forms have different chemical and physical properties, and the selection of the desired form will depend on the specific application of the compound.

In conclusion, the synthetic routes to 4-bromo-5-(1-pyrrolidinyl)-3(2H)-pyridazinone are numerous and varied, and the choice of route depends on several factors, including the desired yield, cost, and availability of starting materials.
The compound has a wide range of potential applications in the chemical industry and can be converted into different forms for specific uses.
The synthetic routes to this compound are an active area of research, and new methods are currently being developed