-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
The production of 4-oxo-1-phenyl-1,4-dihydro-3-pyridazinecarboxylic acid is an important process in the chemical industry, as this compound is widely used as an intermediate in the synthesis of various drugs and other pharmaceuticals.
One of the most common methods of synthesizing 4-oxo-1-phenyl-1,4-dihydro-3-pyridazinecarboxylic acid is through a multi-step synthesis route that involves several chemical reactions.
The first step in the synthesis of 4-oxo-1-phenyl-1,4-dihydro-3-pyridazinecarboxylic acid is the production of 4-aminophenol, which is then converted into 4-hydroxyphenyl acetate through a reaction with acetic anhydride in the presence of a strong acid catalyst such as sulfuric acid.
This intermediate is then hydrolyzed in water to yield 4-hydroxyphenylamine.
The next step in the synthesis of 4-oxo-1-phenyl-1,4-dihydro-3-pyridazinecarboxylic acid involves the reduction of 4-hydroxyphenylamine to yield N-phenylhydroxylamine through a reduction reaction using a reducing agent such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst such as palladium on barium sulfate.
The next step in the synthesis of 4-oxo-1-phenyl-1,4-dihydro-3-pyridazinecarboxylic acid involves the coupling of N-phenylhydroxylamine and benzaldehyde in the presence of a coupling reagent such as hydroxylamine or oxalic acid to yield N-(1-phenyl-1,4-dihy
