The Synthetic Routes of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE

IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE is an important organic compound that has wide applications in the chemical industry.
This compound is synthesized through various synthetic routes, each of which has its own advantages and disadvantages.
In this article, we will discuss the most commonly used synthetic routes for IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.

Route 1: via 1,2-Dihydropyridine-2,3-Dicarboxylic Acid

1,2-Dihydropyridine-2,3-Dicarboxylic Acid is a key intermediate in the synthesis of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This acid can be synthesized through a variety of methods, including the reaction of anhydrous maleic anhydride with aqueous ammonia, the reaction of cyanamide with an excess of malonic acid, or the oxidation of 1,2-dihydro-2,3-diaminopropane.
The resulting acid can then be hydrolyzed to yield the desired compound.

Route 2: via 2,3-Dihydropyridine-1,2,3-Tricarboxylic Acid

2,3-Dihydropyridine-1,2,3-Tricarboxylic Acid is another important intermediate in the synthesis of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This acid can be synthesized by treating 2,3-diaminopropane with phthalic anhydride in the presence of a catalyst, such as aluminum chloride.
The resulting acid can then be hydrolyzed to yield the desired compound.

Route 3: via 6-Amino-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid

6-Amino-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid is a key intermediate in the synthesis of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This acid can be synthesized by treating 6-aminocaproic acid with aqueous hydrochloric acid, followed by treatment with a reactive aromatic compound, such as chloroform or methyl iodide.
The resulting acid can then be hydrolyzed to yield the desired compound.

Route 4: via 6-Amino-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid (from 3,4-dihydro-2H-pyrano[2,3-b]quinoline-1,2-dicarboxylic acid)

3,4-dihydro-2H-pyrano[2,3-b]quinoline-1,2-dicarboxylic acid is another important intermediate in the synthesis of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This acid can be synthesized by treating 2,3-diaminonapthalene with a reactive aromatic compound, such as chloro