The Synthetic Routes of methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate

The Synthetic Routes of methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate

The pursuit of new drugs and the development of the pharmaceutical industry have led to a growing need for new and innovative synthetic methods.
In this regard, the Synthetic routes of methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate, a novel compound with potential pharmaceutical applications, have been the subject of extensive research.

This compound is a unique synthesis of several structural units, making its synthesis challenging and complex.
As a result, various synthetic routes have been developed to address this challenge.
In this article, we will discuss the different synthetic methods that have been employed in the synthesis of methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate.

1. Heterocyclic Synthesis

Heterocyclic synthesis is a widely used method for the synthesis of this compound.
It involves the construction of the 1,2-cyclopropanacyclotetradecaphan heterocycle, which is a key structural unit of the compound, using various heterocyclic synthesis methods.
The use of readily available building blocks, such as 1,3-oxazolidin-2-ones and 1,3-oxazolidin-4-ones, has been proposed as a convenient method for the synthesis of the 1,2-cyclopropanacyclotetradecaphan ring.

1. Pd/C-catalyzed redox homologation

Pd/C-catalyzed redox homologation is another synthetic method that has been employed in the synthesis of methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate.
This method involves the use of Pd/C as a catalyst to promote the redox reaction between the building blocks, leading to the formation of the target compound.

1. Direct reaction of an iodoalkene with (S)-2-iodomalonate

Direct reaction of an iodoalkene with (S)-2-iodomalonate is another method that has been employed in the synthesis