The Synthetic Routes of N-[1,1'-Biphenyl]-2-yl-9,9-dimethyl-9H-fluoren-2-amine

N-[1,1'-Biphenyl]-2-yl-9,9-dimethyl-9H-fluoren-2-amine, also known as BFHP, is an important intermediate in the synthesis of a wide range of chemicals and pharmaceuticals.
This article will discuss the various synthetic routes that can be used to produce N-[1,1'-Biphenyl]-2-yl-9,9-dimethyl-9H-fluoren-2-amine, as well as the advantages and disadvantages of each method.

One of the most common methods for synthesizing BFHP is through the reaction of 2-chloro-9,9-dimethyl-9H-fluoren-1-one with 1-(2'-biphenyl-3-yl)-3-(4,4,5,5-tetradecyloxy)butane.
This reaction is carried out in the presence of a base, such as sodium hydroxide, and is typically performed in a solvent such as N,N-dimethylformamide or N-methyl-2-pyrrolidone.
The product can be isolated by filtering the reaction mixture and then washing the solid with a solvent such as dichloromethane.

Another synthetic route to BFHP involves the reaction of 2-nitro-9,9-dimethyl-9H-fluoren-1-one with 1-iodo-3-(4,4,5,5-tetradecyloxy)butane in the presence of a catalyst, such as sodium hydrogen carbonate or 18-crown-6.
This reaction can be carried out in a solvent such as acetonitrile, and the product can be isolated by filtering the reaction mixture and then washing the solid with a solvent such as ethyl acetate.

A third synthetic route to BFHP involves the reaction of 2-chloro-9,9-dimethyl-9H-fluoren-1-one with 1-(2'-biphenyl-3-yl)-3-bromopropane in the presence of a base, such as potassium carbonate.
This reaction can be carried out in a solvent such as N,N-dimethylformamide, and the product can be isolated by filtering the reaction mixture and then washing the solid with a solvent such as dichloromethane.

Each of these synthetic routes has its own advantages and disadvantages.
For example, the first synthetic route is relatively simple and can be performed using readily available reagents.
However, it requires the use of a solvent such as N,N-dimethylformamide, which can be expensive and potentially hazardous to handle.
The second synthetic route requires the use of a catalyst, which can add to the overall cost of the synthesis.
However, the reaction can be performed using a simple solvent such as acetonitrile, which is less expensive than N,N-dimethylformamide.
The third synthetic route involves the use of a bromide, which can be more expensive and potentially more hazardous to handle than other reagents.

Overall, N-[1,1'-Biphenyl]-2-yl-9,9-dimethyl-9H-fluoren-2-amine is a valuable intermediate that can be produced through a variety of synthetic routes.
The choice of route will depend on factors such as the availability and cost of the starting materials, the reaction conditions, and the desired yield and purity of the product.
Regardless of the route used, proper safety precautions and handling procedures should be followed to ensure the safety of the synthesis team and the environment.