The T-cell-function TIDE algorithm predicts the efficacy of immunotherapy.

Nature Medicine: T-cell-related TIDE algorithm predicts immunotherapeutic efficacy (1) integrates data from 189 cases of a total of 33,197 cancer samples, developed the tumor immunodeficiency disorder and rejection (TIDE) calculation framework based on the analysis and modeling of T-cell rejection characteristicgenes in CTL high levels of T-cell dysfunction and immunosuppressed; Poor efficacy, short survival after treatment with ICB, (3) Using TIDE algorithm to analyze the pre-treatment RNA-Seq or NanoString tumor expression spectrum data, TIDE's predictive efficacy of ICB first-line treatment of melanoma was better than markers such as PD-L1, mutant load and IFN-xenon, and (4) TIDE discovered a new ICB drug resistance control factor SERPINB9.
the important role of chemochemical sorcration factors in pancreatic cancer immuno-escape (1) pancreatic cancer malignant and poor response to immunotherapy such as cell cycle checkpoint inhibitors (ICB); (2) Li, etc., isolated and cultured cell lines from pancreatic cancer tissues of gmiatric mice KPC, screened out T-cell activation (T-inflame) and inactive phenotypes; (3) similar to lung cancer and melanoma. Pancreatic cancer formed by the -inflame cell line is also CD8-T cell immersion, expressing Tim, CTLA4, PD1, Lag3 and other ICB sensitive markers;
metabolism and immunotherapy (1) Tumor microenvironment promotes tumor growth, inhibits immunity, and affects the efficacy of immunotherapy.
combined with metabolic therapy of targeted immune cells and immunocheckpoint inhibitors, can improve efficacy (2) L-arginine cationic amino acid transportors and nitric oxide enzyme-related to arginine metabolism activated epoxy 2, both conducive to the growth of melanoma (3) Amine-2, 3-dioxyrtase (IDO1) is a speed-limiting enzyme for tryptophan metabolism, ifN-gamma and IDO1 inhibitor combination therapy is more effective (4) rapamycin target protein (mTOR) that affects the tumor immune and metabolic microenvironment.
hypoxia inhibition mTOR, promote tumor process (5) to study the metabolic mechanism of immune cells, etc., is conducive to tumor immunotherapy Source: Xinhua Yun Health.