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Scientists at the University of Cambridge used cryoscopic mirrortechnolog to detail the tau protein fibrous structure of Pike's disease, according to a neuroscience study published in the British journal Nature.
Pike disease is a neurodegenerative disease characterized by frontal temporal dementia, and the results will promote awareness and understanding of neurodegenerative diseases.
microtube system is a component of the skeleton of nerve cells that can participate in a variety of cellular functions.
microtubals are made up of microtube proteins and microtube-related proteins, and tau proteins are the most high-content microtube-related proteins.
many neurodegenerative diseases have the characteristics of tau protein aggregation and form protein fibers in the brain.
tau protein may contain 3 or 4 microtube binding repeat fragments (3R or 4R), while tau protein fiber may contain 3R tau, 4R tau, or a combination of both.
in the latest study, Michael Goldett, a researcher at the Molecular Biology Laboratory at the University of Cambridge, and others, used cryoelectric mirrors (cryo-EM) to determine the structure of tau protein fibers extracted from the frontal cortex of patients with Peake.
they had previously reported tau protein fibrous structures in Alzheimer's patients and noted that they contained 3R and 4R tau.
now, the team found a new 3R tau single-chain folding that differs from the tau protein fiberfold in the brains of People with Alzheimer's.
found that the disease-specific folding of tau protein fiber further supports the hypothesis that different fibrous tau protein formations lead to different clinical epithelials.
cracking these different folding patterns and shapes can help to further deepen understanding of a large number of protein abnormal lysathing-related diseases.
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