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Original title: High-quality functional animal products team revealed selenium to improve myocardial health new mechanism
Recently, high-quality function
animal products
team research revealed selenium by improving
antioxidant
enzyme TXNRD and GPX activity to improve the new mechanism of cardiomyopathy, selenium-enhanced animal product development has important guiding significance. The findings were published online in metal
and were selected as cover articles.
, selenium plays an important role in maintaining the body's redox balance, improving immunity and fighting infection, according to zhang Junmin, the team's chief researcher. Prior to this, the team has made important research progress in the product development and nutritional function evaluation of selenium-enhanced meat and eggs. On the basis of the early stage, the researchers successfully constructed the oxidative stress model of in vivo and in vitro heart cells, and found that selenium supplementation can improve the activity of selenium protein TXNRD and GPX, and alleviate oxidative stress-induced cardiomyocyte cycle blocking. Further studies have found that selenium treatment activates the PI3K/AKT signaling path, and inhibition of PI3K significantly weakens the protective effect of selenium on myocardial cells. Studies show that selenium can play an antioxidant role by increasing selenium protein expression, activating the PI3K/AKT pathway, targeting the G2/M stage suppression system, and then participating in the regulation of myocardial cell cycle process.
the study was supported by the National Key Research and Development Program (2018YFD050040001-02/03), the National Natural Science Foundation of China (31802073) and the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences (ASTIP-IAS-12).
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