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As the "gate" of the brain, the blood-brain barrier can be described as a "bronze wall and iron wall"
.
On the one hand, it can prevent harmful substances from entering the brain, giving unlimited protection to the brain, so that the brain is protected from harm; but on the other hand, due to this barrier function, it greatly increases the difficulty of drugs entering the brain and increases the treatment of brain diseases.
Difficulties
.
According to reports, the blood-brain barrier can block about 98% of molecular transport, which is a major challenge for the treatment of brain diseases (such as Parkinson's disease and Ezheimer's disease)
.
How to break through the "goalkeeper" defense of the blood-brain barrier has always been a hot issue in the field of brain-targeted drug research
.
In addition, a large number of studies in recent years have shown that the blood-brain barrier is also actively involved in mediating the exchange of information between the nervous tissue and the circulatory system
.
Damage to the integrity and function of the blood-brain barrier plays a key role in the occurrence and development of cranial nerve and cerebrovascular diseases
.
Therefore, this double-sided role of both barrier and media makes the blood-brain barrier a unique target for the treatment of brain diseases
.
Advanced Science recently published by Professor Li Jia and Professor Zheng Meng from Henan University, Professor Olga Shimoni from the University of Technology Sydney, Professor William A.
Banks from the University of Washington, Professor Ashley I.
Bush from the University of Melbourne, and Professor Jennifer R.
Gamble from the University of Sydney.
And the review article "Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier" co-authored by Professor Bing Yang and others (DOI: 10.
1002/advs.
202101090)
.
This review first summarizes the constituent elements of the blood-brain barrier and the main factors that regulate its structural integrity and normal function
.
The author then discusses using these factors as the main targets and using strategies to enhance these key factors to maintain or restore the integrity of the blood-brain barrier to treat related neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.
) And cerebrovascular diseases (stroke, vascular cavernous malformations, etc.
)
.
Next, the author analyzes how to open the blood-brain barrier by inhibiting factors related to the integrity of the blood-brain barrier from the opposite path
.
The paper focuses on the use of inhibiting tight junction gap proteins and increasing transcytosis to directly regulate the integrity of the blood-brain barrier, as well as physical methods (such as positioning microwave ultrasound, etc.
) and chemical methods (controllable inflammation, angiogenesis, oxidation, etc.
) Cytoskeleton reorganization, etc.
) to indirectly open the blood-brain barrier strategy and progress in preclinical and clinical studies, and summarize how to penetrate the blood-brain barrier through nano-preparations while maintaining the integrity of the blood-brain barrier
.
Subsequently, the paper took cranial nerve inflammation as an example to analyze how to treat cranial nerve inflammatory diseases by restoring the integrity of blood vessels and how to use inflammation and inflammatory cells to deliver drugs to penetrate the blood-brain barrier, so as to achieve the purpose of treatment and further highlight The blood-brain barrier plays a unique dual role in the treatment of related brain diseases
.
Finally, this review discusses the major issues and development directions that need to be resolved in the development of brain-targeted therapeutic drugs targeting the blood-brain barrier
.
This paper provides a timely and beneficial reference for the in-depth development of brain-targeted therapeutic drugs
.
WILEY paper information: Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to CarrierJia Li, Meng Zheng, Olga Shimoni, William A.
Banks, Ashley I.
Bush, Jennifer R.
Gamble, Bingyang ShiAdvanced ScienceDOI: 10.
1002/advs.
202101090 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 15.
840, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into Q1 area of materials science and Q1 area of engineering technology
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
.
On the one hand, it can prevent harmful substances from entering the brain, giving unlimited protection to the brain, so that the brain is protected from harm; but on the other hand, due to this barrier function, it greatly increases the difficulty of drugs entering the brain and increases the treatment of brain diseases.
Difficulties
.
According to reports, the blood-brain barrier can block about 98% of molecular transport, which is a major challenge for the treatment of brain diseases (such as Parkinson's disease and Ezheimer's disease)
.
How to break through the "goalkeeper" defense of the blood-brain barrier has always been a hot issue in the field of brain-targeted drug research
.
In addition, a large number of studies in recent years have shown that the blood-brain barrier is also actively involved in mediating the exchange of information between the nervous tissue and the circulatory system
.
Damage to the integrity and function of the blood-brain barrier plays a key role in the occurrence and development of cranial nerve and cerebrovascular diseases
.
Therefore, this double-sided role of both barrier and media makes the blood-brain barrier a unique target for the treatment of brain diseases
.
Advanced Science recently published by Professor Li Jia and Professor Zheng Meng from Henan University, Professor Olga Shimoni from the University of Technology Sydney, Professor William A.
Banks from the University of Washington, Professor Ashley I.
Bush from the University of Melbourne, and Professor Jennifer R.
Gamble from the University of Sydney.
And the review article "Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier" co-authored by Professor Bing Yang and others (DOI: 10.
1002/advs.
202101090)
.
This review first summarizes the constituent elements of the blood-brain barrier and the main factors that regulate its structural integrity and normal function
.
The author then discusses using these factors as the main targets and using strategies to enhance these key factors to maintain or restore the integrity of the blood-brain barrier to treat related neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.
) And cerebrovascular diseases (stroke, vascular cavernous malformations, etc.
)
.
Next, the author analyzes how to open the blood-brain barrier by inhibiting factors related to the integrity of the blood-brain barrier from the opposite path
.
The paper focuses on the use of inhibiting tight junction gap proteins and increasing transcytosis to directly regulate the integrity of the blood-brain barrier, as well as physical methods (such as positioning microwave ultrasound, etc.
) and chemical methods (controllable inflammation, angiogenesis, oxidation, etc.
) Cytoskeleton reorganization, etc.
) to indirectly open the blood-brain barrier strategy and progress in preclinical and clinical studies, and summarize how to penetrate the blood-brain barrier through nano-preparations while maintaining the integrity of the blood-brain barrier
.
Subsequently, the paper took cranial nerve inflammation as an example to analyze how to treat cranial nerve inflammatory diseases by restoring the integrity of blood vessels and how to use inflammation and inflammatory cells to deliver drugs to penetrate the blood-brain barrier, so as to achieve the purpose of treatment and further highlight The blood-brain barrier plays a unique dual role in the treatment of related brain diseases
.
Finally, this review discusses the major issues and development directions that need to be resolved in the development of brain-targeted therapeutic drugs targeting the blood-brain barrier
.
This paper provides a timely and beneficial reference for the in-depth development of brain-targeted therapeutic drugs
.
WILEY paper information: Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to CarrierJia Li, Meng Zheng, Olga Shimoni, William A.
Banks, Ashley I.
Bush, Jennifer R.
Gamble, Bingyang ShiAdvanced ScienceDOI: 10.
1002/advs.
202101090 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 15.
840, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into Q1 area of materials science and Q1 area of engineering technology
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
