The team of Professor Hu Yongfei from China Agricultural University has constructed the largest chicken gut microbial reference genome and gene set in the world

Recently, the team of Professor Hu Yongfei from the College of Animal Science and Technology of China Agricultural University published the title "metagenome-assembled genomes and gene catalog from the chicken gut microbiome aid research papers in deciphering antibiotic resistomes "of
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By integrating the study of chicken gut microbes macro gene set of data, constructed by far the largest international chicken intestinal microbial genomes and reference Gene collection

A large number of studies have shown that intestinal microbes are closely related to the health of the host
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In poultry, intestinal microbes have been shown to be closely related to food digestion and absorption, immune system development, fat accumulation, growth and development

The study conducted an integrated analysis of 799 chicken gut microbial metagenomic data from a total of ten countries in China and Europe
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The high-quality bacterial/archaea reference genomes at the level of 12,339 strains were assembled, and these genomes covered 1978 microbial species (Figure 1)

On the basis of genome assembly, the research further constructed a chicken gut microbial reference gene set containing 16.
6 million non-redundant genes
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Through the gene function annotation, it is found that the main carbohydrate active enzyme in the chicken intestine is glycoside hydrolase; compared with European-origin chickens, the abundance of drug-resistant genes contained in the intestinal microbes of Chinese-origin chickens is relatively high, but Diversity is low

Figure 12,339 reference genomes and 16 million reference genes were assembled from 799 chicken gut microbial metagenomic samples
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(A) The evolutionary tree of 1970 bacteria and 8 archaea

The reference genome and gene collection data obtained from the research integration are stored in the National Microbial Science Data Center of the Institute of Microbiology, Chinese Academy of Sciences (https://nmdc.

cn/icrggc/) for public access and download

Professor Hu Yongfei from the School of Animal Science and Technology of our school is the corresponding author of the paper, Dr.
Yuqing Feng, a postdoctoral fellow from the School of Animal Science and Technology, is the first author of the thesis, researcher Zhu Baoli from the Institute of Microbiology of the Chinese Academy of Sciences, and Academician Gao Fu, and Professor Yuming Yuming from the School of Animal Science and Technology of our school as co-authors
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The research was supported and helped by researcher Ma Juncai and Wu Linhuanzheng senior engineer of the National Microbiological Science Data Center in data storage and maintenance