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Editor in charge: Food Science
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The team of Professor Wang Huimin of Chung Hsing University published a study "Bifunctional mechanisms of autophagy and apoptosis regulations in melanoma from Bacillus subtilis natto fermentation extract" in the top international food science journal FOOD AND CHEMICAL TOXICOLOGY (2020 Impact Factor 4.
Summary:
The two extracts obtained from natto: freeze-dried natto extract (NFDE) and natto water extract (NWE), both have the potential to develop into anti-melanoma drugs.
Keywords: Bacillus subtilis natto extract; melanoma; oxidative stress; autophagy; apoptosis
Melanoma:
Melanoma cancer develops from melanocyte lesions.
Natto extract:
Natto is a traditional Japanese food.
Results and discussion :
This study found that natto extract at very low concentrations (< 3 µg / ml) or in a short period of time (< 6 h) will first induce autophagy.
In terms of molecular machinery, AMPK reacts to changes in energy.
in conclusion:
The natto extract obtained by freeze-drying method and water extraction method can have a therapeutic effect on melanoma cancer.
about the author
Professor Wang Huimin, currently working in the Institute of Medical Engineering of Zhongxing University; graduated from the Department of Chemical Engineering of Chenggong University in 2003 with a doctorate degree.
In the past time, Professor Wang has published nearly 200 SCI international papers, including Angewandte Chemie-International Edition , Chemical Science , Bioresource Technology , ACS Applied Materials & Interfaces , Nanoscale , ACS Applied Bio Materials , Molecular Nutrition & Food Research , Food and Chemical Toxicology , Cell Death & Disease , Oxidative Medicine and Cellular Longevity , Journal of Cellular and Molecular Medicine , Antioxidants , Journal of Functional Foods , Food Science and Human Wellness ,Journal of Agricultural and Food Chemistry , which covers cancer research, biomaterials, nanoparticles, skin drugs, green sustainable energy and bioactive substance applications.
The article "Bifunctional mechanisms of autophagy and apoptosis regulations in melanoma from Bacillus subtilis natto fermentation extract" was published online in Food and Chemical Toxicology on January 26, 2021 .
