The team of Professor Liu Shiping from Three Gorges University discovered that the new antibacterial pentapeptide can effectively prevent postharvest fruit spoilage

Recently, the team of Professor Liu Shiping from China Three Gorges University published an article entitled "A linear pentapeptide from Penicillium oxalicum-Trigorin, which can inhibit citrus green mold" in Food Chemistry, a top international agricultural and food journal.
"The growth of citrus" (Sanxiapeptin, a linear pentapeptide from Penicillium oxalicum, inhibited the growth of citrus green mold), reported that the three gorges peptide derived from the filamentous fungi on the banks of the Three Gorges River can effectively inhibit the postharvest rot fungi of fruits.
It laid the foundation for the development of new peptide fruit antistaling agent
.

The article takes Three Gorges University as the only unit to complete the article, with master's student Yang Yuchun as the first author, and Professor Liu Shiping as the corresponding author
.

In recent years, with the abuse of antibiotics and the frequent emergence of drug-resistant strains, antimicrobial peptides, as a substitute for antibiotics, have attracted widespread attention from the world and are a class of substances that scientists have been looking for for a long time
.

After nearly 8 years of hard work, the research group started from the citrus orchards distributed in the river bank of the Three Gorges, and isolated a new linear antibacterial pentapeptide from the fermentation broth of a filamentous fungus Penicillium oxalicum, named Three Gorges peptide Su (Sanxiapeptin)
.

The substance is composed of 5 amino acids, namely β-amino-α-methoxybutyric acid (Amoba), N-Me-L-Thr, D-Thr, N-Me-L-Val and L-Ser
.

Since Penicillium oxalicum has been used in agriculture for many years as a biological control fungus, but its antibacterial substances are still uncertain, this research has laid a solid foundation for clarifying the biological control mechanism of Penicillium oxalicum
.

Further analysis showed that, whether in vivo or in vitro, TGP can significantly inhibit the growth of postharvest rot-causing fungus Penicillium digitatum in oranges, grapes and other fruits
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By comparing three chemically synthesized oligopeptides with similar structures, it was found that the methylation of the first amino acid and peptide bond of Amoba is the key to inhibiting fungal activity
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Its antibacterial target is the cell surface such as cell membrane or cell wall
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Three gorges peptide is completely non-toxic to the human body and the environment, has no side effects, and has a stable effect.
Its effect is far better than the commonly used pesticide Baicai, which is monopolized by Japan.
It can significantly improve the shelf life of citrus fruits.
A promising antibacterial agent for fruit preservation
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This research work was supported by the Hubei Provincial Key Laboratory of Natural Products Research and Utilization, the Chinese Light Industry Functional Yeast Key Laboratory, the National Natural Science Foundation of China and the Yichang Natural Science Foundation
.

Link to the paper: https://doi.
org/10.
1016/j.
foodchem.
2021.
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