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    Home > Food News > Food Articles > The team of Professor Sun Yongxue of the College of Veterinary Medicine of South China Agricultural University has made new progress in the field of environmental ecotoxicology of veterinary drugs

    The team of Professor Sun Yongxue of the College of Veterinary Medicine of South China Agricultural University has made new progress in the field of environmental ecotoxicology of veterinary drugs

    • Last Update: 2022-11-15
    • Source: Internet
    • Author: User
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    Recently, the team of Professor Sun Yongxue of the College of Veterinary Medicine of South China Agricultural University has made progress in the remediation technology of antibiotic contamination from aquaculture sources, and the latest result "Enhancement of biological denitrification by the addition of novel sRNA Pda200 under antibiotic pressure" (https://doi.
    128113) Published in the internationally renowned journal Bioresource Technology (Zone I, Impact Factor 11.
    889), which is followed by Environmental Pollution (Zone II, Impact Factor 9.
    988), Ecotoxicology and Environmental Safety (Region II, impact factor 7.
    129) and other journals published the third research paper
    on phased results.
    This study used the combination of antibiotic-induced denitrification regulatory sRNAs and high-efficiency denitrification polymers to confirm that sRNA Pda200 can bind to specific denitrification functional genes under antibiotic stimulation, thereby significantly enhancing the nitrogen removal performance
    of multiple classes of denitrifying bacteria in antibiotic-contaminated environments.
    The results of this study explore the synergistic strategies for biological nitrogen removal in aquaculture wastewater from the perspective of post-transcriptional expression of denitrifying bacteria, which provides a new idea
    for the simultaneous removal of high concentrations of nitrogen compounds and antibiotic residues in aquaculture habitats.
    In recent years, Sun Yongxue's team has carried out a series of studies on the interference mechanism of antibiotic residues on environmental nitrogen metabolism, the molecular response of denitrification process under antibiotic stress, and the adaptation law and remediation application of denitrifying bacteria in polluted habitats, which establishes a foundation for elucidating the co-metabolic degradation mechanism of antibiotics by denitrifying bacteria and provides guidance for
    the development of new environmental remediation enhancers.
    In 2020, the team used metagenomics technology to analyze the distribution of resistance groups of microbial communities in antibiotic-contaminated soil for the first time in relation to the nitrogen cycle, revealing that the risk of resistance induced by the introduction of antibiotics into the environment can be accompanied by the diffusion of nitrogen metabolism pathways, which provides a theoretical basis
    for controlling the transmission of resistance genes through the environment.
    The paper "The bacterial microbiota in florfenicol contaminated soils: The antibiotic resistome and the nitrogen cycle" is in the international journal Enviro Published in nmental pollution (https://doi.

    In 2021, the team identified multiple antibiotic-induced sRNAs in the model strain Paracoccus denitrificans for the first time through prokaryotic transcriptome sequencing, capturing the real-time transcription map of denitrifying bacteria under antibiotic interference, which provided a reference
    for the control of antibiotic environmental pollution.
    The related paper "Response characteristics of nirS-type denitrifier Paracoccus denitrificans under florfenicol stress" is in the international journal Ecotoxicology and Enviro Published in nmental safety (https://doi.

    The above series of studies were completed on the National Veterinary Microbial Drug Resistance Risk Assessment Laboratory, the National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory (South China Agricultural University) and other platforms, and were supported by the National Natural Science Foundation of China (31772803), Guangdong Pearl River Talent Program Local Innovation Scientific Research Team Project (2019BT02N054) and other supports, 2019 doctoral student Wang Mei is the first author of the above 3 papers, and Professor Sun Yongxue is the corresponding author
    of the papers.
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