echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > The team of Professor Xia Ningshao of our hospital constructed a new live chickenpox vaccine with skin and nerve double attenuation properties

    The team of Professor Xia Ningshao of our hospital constructed a new live chickenpox vaccine with skin and nerve double attenuation properties

    • Last Update: 2022-03-08
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Chickenpox is a highly contagious common skin disease of children caused by primary infection with the varicella - zoster virus ( VZV ) .


    In this study, the researchers constructed the VZV Oka strain VZV-7D that lacks the expression of the virulence factor ORF7 , and applied a variety of in vitro and in vivo infection models, including human skin and nerve cell in vitro models, human skin / nerve tissue chimeric mice model, guinea pig model, cotton rat model, and primate model, systematically verified that the attenuated phenotype of VZV-7D in skin and nerve tissue can avoid the potential harm of varicella and herpes zoster after long-term latent reactivation.


    Potential safety and efficacy of skin and nerve double attenuated varicella vaccine VZV-7D

    Recently, the research results were published online in Nature Communications in a paper entitled "Development of a skin-and neuro-attenuated live vaccine for varicella " .


    Paper link: https://

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.