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    Home > Food News > Food Articles > The team of Professor Yingmin Jia and Professor Ma Aijin, School of Food and Health, Beijing Technology and Business University: Anti-inflammatory and intestinal flora regulation effects of walnut peptide LPF in the body

    The team of Professor Yingmin Jia and Professor Ma Aijin, School of Food and Health, Beijing Technology and Business University: Anti-inflammatory and intestinal flora regulation effects of walnut peptide LPF in the body

    • Last Update: 2021-12-24
    • Source: Internet
    • Author: User
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    Editor in charge: Food Science


    Walnut is a kind of functional food with high phytochemical content
    Fat-soluble biologically active substances are a research hotspot in the functional food market

    Inflammatory bowel disease (IBD) is a common chronic gastrointestinal disease

    Ulcerative coltis (UC) is a subtype of IBD, which is manifested as colonic epithelial cell-related mucin damage, innate immune response activation caused by changes in the intestinal environment, and adaptive immune system disorders

    Bioactive peptides extracted from dietary protein have been used in the adjuvant treatment of IBD

    However, so far, there have been few reports on the regulatory effects of walnut derived peptides on UC


    In this study, Tongxin Zhi (first author), Jia Yingmin*, Ma Aijin* and others from the School of Food and Health of Beijing Technology and Business University studied the walnut peptide leucine-proline-phenylalanine (leucine-proline-phenylalanine).
    , LPF) protects and restores colitis in mice induced by dextran sulfate sodium (DSS)

    The changes in body mass, disease activity index score and serum inflammatory cytokine levels can show that peptide LPF can alleviate the severity of symptoms in the development stage of colitis

    In addition, the treatment group showed beneficial effects, including increasing colon length, reducing colon cell apoptosis, reducing the production of inflammatory factors, and the expansion of splenic regulatory T cells during the recovery period

    In addition, 16S rDNA sequencing results showed that 100 mg/kg LPF (M group) reversed the imbalance of the intestinal flora of colitis mice

    This includes the stages of development of colitis, flora diversity partial recovery, Lachnospiraceae (
    Lachnospiraceae ) and rumen Cocci Section ( Ruminococcaceae ) increase in relative abundance
    In addition, compared with the DSS group, the composition of the intestinal flora in the M group continued to improve during the recovery period of colitis, the relative abundance of beneficial genera increased, and the abundance of potentially harmful genera decreased


    In summary, the walnut peptide LPF can relieve the symptoms of colitis and promote recovery by reducing cell apoptosis, anti-inflammatory effects and regulating intestinal flora
    This research supports the use of walnut peptide LPF as a functional food additive to prevent and relieve colitis

    The absorption and metabolism mechanism of walnut peptide LPF in the body and the potential influence of intestinal flora on its anti-inflammatory response need further research


    Project funding:

    Hebei Province Major Scientific and Technological Achievement Transformation Project (Project No.
    Hebei Province Innovation and Entrepreneurship Team Project (Project No.

    Corresponding author introduction

    Professor Yingmin Jia

    School of Food and Health, Beijing Technology and Business University

    Jia Yingmin, Doctor of Science, Professor, Doctoral Supervisor, Master Supervisor

    The main research areas
    Mainly engaged in enzyme and protein engineering, food microbiology research
    Main academic achievements (topics, papers, awards, patents, etc.

    He has presided over the completion of a number of major national, provincial and ministerial research projects.
    He has won 2 provincial and ministerial-level scientific and technological progress first prizes and 2 scientific and technological progress second prizes.
    1 Provincial Excellent Teaching Achievement First Prize; Obtained a number of national invention patents; Published more than 100 academic papers; Editor-in-chief of the National Tenth Five-Year Plan textbook and one textbook for the 21st century

    Currently, he is in charge of the National Natural Science Foundation of China "Study on the structure analysis and antibacterial mechanism of Brevilacterin of Brevilacterin" and the Beijing Natural Science Foundation of "Research on the Biological Resistance of Brevilacterin of Brevilacterin"


    Professor Ma Aijin

    School of Food and Health, Beijing Technology and Business University

    Ma Aijin, professor, doctoral supervisor, and expert on special government allowances from the State Council
    The main research areas include food and bio-technology and standardization

    In recent years, he has presided over the National Key Research and Development Program of the Ministry of Science and Technology "Research on Common Technical Standards for Biological Industry (2016YFF0202300)" and the National Natural Science Foundation of China "Shrimp sarcoplasmin and its subunit allergenicity and structure-activity relationship Research (31972184)" and more than 30 scientific research projects; presided over and participated in 70 national standards, won 13 provincial and ministerial scientific and technological achievement awards, edited and participated in editing 12 books , and published more than 80 papers in journals such as
    Food Hydrocolloids and Food Chemistry Articles
    He is currently the vice chairman of the National Standardization Technical Committee for Meat, Poultry and Egg Products, a member of the National Standardization Technical Committee for Biochemical Testing, the vice chairman of the Edible Mushroom Postharvest and Processing Industry Branch of the Chinese Mycological Society, a member of the Leading Analysis Expert Committee for Special Food Sampling Inspection,
    Food and Agricultural Immunology editorial, Hebei walnut nutritional function and processing technology Key laboratory academic Committee director

    The article "Anti-Inflammatory and Gut Microbiota Regulatory Effects of Walnut Protein Derived Peptide LPF In Vivo " was published online at Food Research International on December 8, 2021

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