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The team of Yu Xueqing/Zhang Zhenhai/Cao Guangwen jointly reveals the key features of the human antibody repertoire |
Yu Xueqing’s team from Guangdong Provincial People’s Hospital, Zhang Zhenhai’s team from Southern Medical University, and Cao Guangwen’s team from Naval Military Medical University of the People’s Liberation Army jointly published an online study on the characteristics of human antibody repertoires at the population level, revealing that it includes gene usage rates, gene recombination preferences, and public Key features of multiple antibody repertoires including cloning and somatic hypermutation.
On May 11, 2021, the international academic journal "Cell Reports" published the results of this research online.
Antibody repertoire refers to the collection of all antibodies contained in a specific individual or tissue.
Early technologies (ie Sanger sequencing and profiling) greatly restricted the research on antibody repertoires due to low throughput or low resolution.
In view of its huge potential, researchers have produced batch after batch of antibody repertoire sequencing data according to specific research purposes.
Under the guidance of Professor Zhang Zhenhai, PhD students Yang Xiujia, Zhang Yanfang, Zhu Yan, and master student Huikun Zhu collected 2,152 sets of high-quality antibody heavy chain sequencing data sets, including gene usage rates, gene recombination preferences, and public cloning.
Schematic diagram of experimental design and main research results.
Schematic diagram of experimental design and main research results.
In addition, it is worth noting that in the analysis of somatic hypermutation, the team classified each site in the germline sequence of the V gene according to the consequences of the mutation (ie missense mutation or synonymous mutation), thus revealing The positive selection phenomenon of RGYW motif in somatic hypermutation.
"The human antibody repertoire is extremely diverse.
Related paper information: org/10.
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