The Third Military Medical University reveals a new mechanism of tumor immunity

Recently, the research team of the Third Military Medical University published an independently completed original thesis online in
, the top journal of gastroenterology, revealing a new tumor immune mechanism, providing new ideas for gastric cancer immunotherapy, and promising to play an important role in personalized treatment of gastric cancer immunology.
In oncology immunological research, scientists have not focused too much on "neutral granulocytes", and there is no treatment based on neutral granulocytes in actual clinical treatments - not only are these cells short-lived, "live only" 24 hours, but they flow out of the bone marrow and seem to be "passing by" relative to tumor tissue. Studies of the cell have reached the exact opposite conclusion: some have confirmed that neutral granulocytes play a role in promoting T lymphocytes, the "tumor killer", and others have confirmed that they inhibit T cells.
After three years of systematic research, the Research Center of National Immuno-Biological Products Engineering and Technology of the Third Military Medical University, Yu Quanming, and the Manor team found that neutrogenic granulocytes play an important role in regulating T lymphocytes, especially the "double identity" of activation/suppression in the microenceptive environment of stomach cancer tumors.
More importantly, they found that neutral granulocytes rely primarily on an immunosuppressive molecule called PD-L1 to suppress the anti-tumor effects of T lymphocytes, and further found the "regulator" GM-CSF of the factor and its regulatory methods, thus revealing the internal mechanism of neutral granulocytes regulating T lymphocytes.
is of great clinical significance to the research results. "In the immunotherapy of stomach cancer, it is available to choose between the immunosuppressive molecule PD-L1 as a direct target or its 'regulator' GM-CSF as an indirect target, which actually provides new therapeutic ideas," said Manor, one of the co-authors of the communication. "
" PD-L1 positive neutrinoblasts can also be used as a new indicator to monitor the tumor micro-environment, with its response to determine the state of the tumor micro-environment, and thus provide guidance for preoperative regulation, options and postoperative treatment of tumor therapy. Manor further pointed out, "At present, the domestic monitoring of tumor microencology is not enough attention, the discovery is expected to be gradually promoted in the domestic triple-A hospitals, accelerate the narrowing of the gap with developed countries in Europe and the United States, to promote personalized treatment of tumor immunity."
co-authors of the study are Wang Wei, a doctoral student at the research center, and Professor Zhao Yongliang, a general surgery professor at the university's Southwest Hospital, who has fully independent intellectual property rights. (Source: Science Network Zhao Guangli Hu Hongsheng)