The transport of nanoparticles within cells is directly related to their aggregation state.

Recently, the Institute of Physical Biology of the Shanghai Institute of Applied Physics of the Chinese Academy of Sciences, in collaboration with the University of California, San Diego, developed a fluorescent-nanoparticle-based fluorescent-nano plasma dual-modal imaging fPlas probe and studied the effects of its aggregation process and aggregation state on its transmission dynamics in in-cell transport.
results are published in Nature Communications (2017, 5,15646).
and bubble transport are important physiological processes of cell signaling and energy communication.
, the study of the cell swallowing and in-cell transport process of nanoparticles is the basis for the design of new nano-drug vectors and nano-diagnosis methods. Under the guidance of researcher Yu Chunhai and University of California Professor Lal, Dr. Liu Mengmun and Associate Researcher Li Xi of the
Physical Biology Research Office have developed a method of semi-quantitative study of nanoparticle aggregation at the single-cell level, which can clearly distinguish between gold nanoparticles with single dispersion, small aggregates and large aggregates in living cells, and correspond to the green, yellow, and bright yellow particle signals under the darkfield microscope.
they further used nano plasma imaging and fluorescence imaging to achieve the simultaneous acquisition of nanoparticle aggregation and positioning information in living cells.
the gold nanoparticles are transported through microtubes in cells, and the process of gradual aggregation occurs in transit is imaged in real time, and its aggregation state is found to have an important effect on the motion state of the related vesicles.
the results of this study reveal that the transport of nanoparticles within cells is directly related to their aggregation state, providing new ideas and targets for the design of new nanodies.
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