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    Home > Biochemistry News > Biotechnology News > The unknown mechanism of T cell action before the publication of Science sub-journals: signaling pathways necessary for survival

    The unknown mechanism of T cell action before the publication of Science sub-journals: signaling pathways necessary for survival

    • Last Update: 2022-01-09
    • Source: Internet
    • Author: User
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    Like humans, every cell in our body is trying to avoid death as much as possible
    This is especially true for a specific type of immune cell called T lymphocytes (T cells for short)

    These cells can stop viruses, bacteria, parasites and cancer cells

    Although the production of T cells is an active process in infants, children, and young adults, it will gradually stop with age.
    This means that in order to maintain sufficient immunity until old age, your T cells should work with you The same longevity


    How T cells survive in the human body for so long, even for decades, has been unclear for a long time
    In collaboration with scientists from the Department of Biomedicine and sciCORE, the University of Basel’s Scientific Computing Center, Professor Jean Pieters’ research team at Biozentrum has now revealed the existence of a hitherto unrecognized pathway to promote the long-term survival of T cells

    In the journal Science Signals, they reported that this signaling pathway regulated by the protein coronin 1 is responsible for inhibiting T cell death


    Coronin 1

    In early research, Pieters' team and others have shown that coronin 1 is essential for the survival of peripheral T cells, as well as for their production and maturation
    In their current research, the team has now been able to show that the pathway previously thought to be related to T cell survival is actually independent of coronin 1.
    They have further discovered an unknown coronin 1 driven signaling pathway that regulates T cells.


    In order to find this approach that relies on coronin 1, the researchers set up a program to collect high-purity T cells, and then analyze the entire RNA molecules in normal and coronin-1 deficient T cells
    Somewhat unexpectedly, an in-depth bioinformatics analysis of a large amount of data did not find any difference between the two groups of T cells

    "At that time, the blockade caused by covid -19 began, so I decided to use my time at home to screen many gene lists to see if there is any connection with known signaling pathways, and the relaxation of these signaling pathways Regulation can explain the disappearance of T cells in the absence of coronin 1.


    Researchers reveal unknown pathways

    Surprisingly, there is a positive match between coronin 1-dependent T cell survival and the pathway of lipid kinase PI3Kdelta to modify the plasma membrane
    With the assistance of Professor Matthias Wyman, a PI3K expert in the Department of Biomedicine, the researchers pieced together the various parts of the puzzle, making them realize that coronin 1 maintains the activity of PI3Kdelta and in this way inhibits the death of T cells


    Pieters said: "Follow-up studies on these findings will be exciting, not only to understand the role of other members of the coronavirus family in cell survival, but also to understand how cell populations, such as circulating T cells in the blood, are maintained for a long time.

    "Finally, given the importance of T cells in the regulation of various processes, such as drug-resistant viral and microbial pathogens, tumorigenicity and autoimmunity, this work may help to better control and is not appropriate Appropriate T cell activity


    Journal Reference :

    1. Mayumi Mori, Julie Ruer-Laventie, Wandrille Duchemin, Philippe Demougin, Tohnyui Ndinyanka Fabrice, Matthias P.
      Wymann, Jean Pieters.
      Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling .
      Science Signaling , 2021; 14 (714) DOI: 10.

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