The use of β-blocker drugs—propranolol may be expected to repair vascular malformations in the brain!

February 28, 2021 // --Recently, a research report titled "Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations" was published in the international magazine Stroke , from Uppsala University Scientists from other institutions have discovered through research that beta blockers may help repair abnormal blood vessels in the brain.

Researcher Peetra Magnusson pointed out that so far, there is no effective drug treatment for this kind of patients, so the results of this article are particularly important, because they may be expected to help develop new therapies for the treatment of cerebral cavernous hemangioma.

Image source: Joppe Oldenburg

The drug propranolol is a beta blocker.

Researcher Magnusson pointed out that we analyzed the vascular malformations in the mouse brain, which corresponded to the human genetic form of the disease, that is, showing cerebral cavernous hemangioma; the researchers added the drug propranyl to the water that the mice drank Lohr, at the same time, observed that cerebral cavernous hemangioma will become less and smaller; at the same time, the vascular function of the mouse body will be significantly improved, and the frequency of vascular leakage events will be reduced, and the blood vessel cells Communication has also been significantly improved.

Finally, the researcher Elisabetta Dejana said that the most interesting point of this study is that the researchers are currently conducting a clinical study in Italy, that is, to allow CCMs patients to receive the two-year drug propranolol treatment; during this period, through the treatment of blood vessels Using magnetic resonance imaging technology for monitoring, researchers can understand the development of vascular malformations in the brains of mice.

Reference materials:

[1] Joppe Oldenburg, Matteo Malinverno, Maria Ascencion Globisch, et al.