The use of human stem cells to develop functional pacing cells.

Scientists at McEwen's Regenerative Medicine Center in Toronto, Canada, used human stem cells to develop the first functional pacing cells, paving the way for biological pacing therapy.
this article, entitled "Sinus cells derived from human pluripotent cells, can act as biological pacemakers" (Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a pacemaker)," is published in Nature Biotechnology, December 12.
study details how physicular erythrocytes are induced and differentiated into pacing cells that use electrical impulses to control the heartbeat within 21 days.
these human pacing cells were tested on laboratory mice, and the results showed that they could work as biological pacemakers by activating electrical impulses that cause the heart to contract.
have the potential to differentiate into more than 200 cells that make up the body's tissues and organs.
cells are the heart's main pacemakers that control the heartbeat throughout life.
problems with the sinus cells can lead to cardiac rhythm disorders, which can usually only be treated with electronic pacing device implants.
to figure out how to produce pacing cells can help understand the causes of pacing cell disorders and provide a source of cells for the development of biological pacemakers.
the prospect of replacing electronic pacemakers, which can overcome many disadvantages, such as lack of hormone response and inability to adapt to the heart size of children.
researchers used a method of developmental biology to develop a specific method to produce pacing cells.
. Gordon Keller, of the McEwen Center, said, "Our job is to do human biology research in petri dishes.
we replicate the natural pacing cell production process.
based on past findings in animal models, researchers at the McEwen Center tested and mapped how human pluripotent stem cells became the development path of pacing cells.
the specific method is to test different signaling molecules at different points in time over a 21-day period to guide cells toward their target.
Stephanie Protze said: "You have to determine the right signaling molecules at the right time to stimulate stem cells at the right concentration.
Keller added: "We understand the importance of biological precision in the growth and development of organisms.
we achieve the same precision in Petri dishes because we copy the same process.
" researchers point out that the Linchuan trial of this biological pacing cell will take another five to ten years, and the next step is to start preclinical safety and reliability trials.
, the researchers were able to use their new technique to generate pacing cells from patients with abnormal pacing function.
they can use these cells to study "diseases in petri dishes" to develop new drugs that improve pacing function.
long term, the team hopes to develop a biological pacemaker to replace the electronic pacemaker.
in Canada, more than 10,000 people are implanted with electronic pacemakers each year, and a total of 120,000 patients now have electronic pacemakers in their bodies.
electronic pacemakers have a life span of between 5 and 10 years, with an average of seven years.
the success of bio-pacemakers, patients will have the hope of lifelong use.
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