The virus was detected in the "self-reported asymptomatic" patients, and one patient was still asymptomatic one week after diagnosis

Novel coronavirus (SARS-CoV-2) was returned from Germany to China in February 18th, and a new communication article was published in the new England Journal of medicine In the case of the closure of the Lihan passage, 126 people (mainly German citizens) in Hubei Province were evacuated to Germany by special plane on February 1, 2020 after receiving symptom screening Considering previous studies have shown that sars-cov-2 has a incubation period of up to 14 days, these passengers will be sent to germersheim in Germany for isolation for 14 days after landing Ten passengers were quarantined during the flight Two of them had contact with one confirmed patient, six had reported or were considered to have clinical symptoms related to new coronavirus disease (covid-19), and the other two were accompanying family members of isolation members After the plane landed, the 10 passengers were immediately sent to Frankfurt University Hospital, and then their throat swabs and sputum samples were tested for nucleic acid The results were all negative for sars-cov-2 The remaining 116 passengers were assessed by the medical team at the Frankfurt Airport medical center Each passenger was asked to report symptoms of fever, fatigue, sore throat, cough, runny nose, muscle soreness or diarrhea, and a doctor screened the nasopharynx for signs of infection In addition, they took a temperature measurement Only 1 person with a temperature of 38.4 ℃ and reported dyspnea and cough was transferred to the Frankfurt University Hospital for further evaluation, and throat swabs and sputum samples were negative Of the 115 passengers who were not feverish, one refused, and 114 others were tested for pharyngeal swab virus Two of them were positive and rechecked through the secondary test Both patients were diagnosed on February 2 and transferred to Frankfurt University Hospital for follow-up evaluation and observation The main medical history of the two patients was as follows: Patient 1: a 58 year old male On January 20, I left for Wuhan, China On the way, I passed Bremen, Munich and Beijing, China Finally, I stayed in Wuhan until I left on February 1 and was diagnosed and hospitalized on February 2 The patient's impression is that there have been no typical symptoms of influenza or respiratory infection in the past few weeks There was no fever during all screening and admission observation Except anemia, there was no abnormality in the laboratory No symptoms were found 7 days after admission There was no cross-section between the patients and the confirmed cases of covid-19 Patient 2: 44 year old female Recalled symptoms include: From January 21 to 23, there was a whole body rash without itching, accompanied by muscle soreness and headache Once had a fever to 38 ℃ Cough and itchy throat on 25 January Denied breathing difficulties and chest pain On January 28, the patient developed ear pain and was suspected of ear canal infection, so he took amoxicillin for 3 days The patient was evacuated on February 1 and admitted to hospital on February 2 After admission, mild skin rash was observed in the chest and legs, and slight pharyngitis was found There was no fever in all the screening process and during the admission observation, the physical signs were normal, and the laboratory examination results were normal He was in good condition 7 days after admission There was no cross-section between the patients and the confirmed cases of covid-19 In addition, in the cell culture experiment, the sars-cov-2 virus strains isolated from the positive samples of the two patients showed potential infectivity During the evacuation process, symptom based screening could not effectively detect sars-cov-2 infection in two passengers; meanwhile, people without signs of infection such as fever or slight signs may also carry potentially infectious viruses (based on the results of cell experiments).