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Theway sugar isogenous is basically the reverse process of glycolysis or sugar aerobic oxidation, most of the enzymatic reactions in the glycolysis pathway are reversible, but the three reaction processes of hexalose
gyease
, phosphate fructose kinase and acetone kinase, all have considerable energy changes.
Because both hexatrophase (including glucose kinase) and fructose fructose kinase catalyzed reactions consume ATP and release energy, acetone kinase catalytic reactions cause phosphatol-type acetone acid to transfer their energy and phosphate to produce ATP, the reverse process of these reactions requires the absorption of equal amounts of energy.
Thus constitutes an "energy barrier", in order to cross the barrier, the realization of sugar heterogeneity, can be catalyzed by different enzymes retrograde process, and bypass their respective energy barriers, this one-way reaction catalyzed by different enzymes, resulting in two agents interoperability of the cycle called the active or substrate cycle.(i) The reverse reaction catalyzed by acetone kinase is accomplished by a two-step reaction first by acetone acetate carbase, which converts acetone acid into oxalacetic acid, and then by phosphatidol-type acetone kinase, which produces phosphate-type acrylic.this process consumes two high-energy bonds (one from ATP and the other from GTP), while only one ATP is generated by the decomposition of phosphate-type acetone acid into acetone acid.Because acetone acetate is present only in mitochondrials, acetone acid in cytosine must enter mitochondrials in order to carbide to produce oxalacetic acid, and phosphatidol-type acetone kinase mitochondrials and cytosine are present, so oxalacetic acid can be directly converted into phosphatidol acrylic acid in the mitochondrials and then into cytosine.
However, oxal acetic acid cannot pass through the mitochondrial membrane, and its entry cell fluid can be transported in two ways: one is by the action of
dhydrogenase
of the apple acid, which is reduced to apple acid, and then through the mitochondrial membrane into the cytosine, and then by the cell fluid NAD-umtic acid dehydrogenase to oxalic acid dehydrogenation into the glycoacetic reaction pathway.
It can be seen that the replacement of folic acid with folic acid through the mitochondrial membrane not only solves the carbon units needed for sugar isogenation, but also brings out a pair of hydrogen from the mitochondrial body, with NADH plus H-plus formation to make 1,3-diphosphate glycerate to produce 3 phosphate glycerides, thus ensuring the smooth progress of glycosphate.
Another way is through the guerilla
traminase
effect, the production of tianmen dongline and then escape out of the granules, into the cell fluid Tianmen dongsine and then through the cytosin glutamate transaminase catalysis catalysis to restore the production of oxal acetyl.
experiments have shown that when sugar is made from acetone acid or certain sugars
amino acids
that can be converted to acetone acid, it is sugar isogenic by mitochondrial way with apple acid, while lactose is sugar Heterogenous reaction, it has dehydrogenated when it became acetone acid in the cell fluid to generate NADH plus H, available for use, so often in the mitochondrial body after the production of oxalacetic acid, and then become Tianmen dongine and out of the membrane into the cytoplasm.(ii) A retrograde process of two reactions catalyzed by hexarose kinase and fructose fructase phosphatecompleted by two specific
phosphatases
hydrolyzed hexaphosphate bonds, catalyzing G-6-P hydrolysis to produce glucose Enzymes for glucose-6-phosphatase (glucose-6-phosphatase);addition to the above-mentioned reactions, the sugar heterogeneous reaction is the reverse reaction process of the sugar enzyme pathway. Therefore, the sugar heterogeneity can be summed up as: 2 acetone acid, 4ATP, 2GTP, 2NADH, 2H2O→ glucose, 2NAD, 4ADP, 2 GDP, 6Pi, 6H,sugar isogenic. Raw materials have lactic acid, glyceros and amino acids, lactic acid in lactic acid dehydrogenase action into acetone acid, by the aforementioned pyride branch into sugar
;
amino acids are used through a variety of channels to become intermediate products in the process of glycolysis or oxygen oxidation of sugar, and then produce sugar;
.
.