-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Although the HPV vaccine can effectively prevent cervical cancer, it is difficult to obtain a single shot, and the price is also prohibitive for many peop.
Although the HPV vaccine can effectively prevent cervical cancer, it is difficult to obtain a single shot, and the price is also prohibitive for many peop.
Guided reading
"Nine prices for a seedling are hard to fi.
"Nine prices for a seedling are hard to fi.
In April 2022, the World Health Organization (WHO) concluded after an assessment and review that a single dose of HPV vaccine and two/three doses of HPV vaccine are equally effective, bringing the need for the vaccine to many peop.
At the same time, this conclusion has also caused controversy: since a single dose of HPV vaccine is effective enough, what is the significance of the existing three-dose vaccine?
01
01WHO's latest conclusion: only one shot of HPV vaccine can be used
WHO's latest conclusion: only one shot of HPV vaccine can be usedIn recent years, with more and more voices calling for women to get HPV vaccine as soon as possible to prevent viral infection and cervical cancer, people have also gained more and more awareness of HPV virus and its preventive vaccin.
The HPV vaccine has finally broken through the tinted glasses that people have produced due to limited cognition, and more and more people have begun to pay attenti.
At present, the HPV vaccine requires three injections of bivalent, quadrivalent or nine-valent vaccines according to age and needs, but in reality, it has been facing problems such as high price, difficult appointments, and long battle lin.
This is unfair to a generation of women who may be at risk for cervical canc.
A recent meeting of the World Health Organization's Strategic Advisory Group of Experts on Immunization (SAGE) reviewed evidence emerging over the past few years that a single-dose regimen of HPV vaccine was comparable in efficacy to a two- or three-dose regim.
This conclusion may change the consistent "rules of the game" for the prevention of cervical cancer and HPV vir.
In its latest conclusions, SAGE recommends updating the dosing table for the HPV vaccine as follows:
- One or two doses for girls aged 9-14
- One or two doses for young women aged 15-20
- Women over 21 receive two doses, 6 months apart
my country's current HPV vaccination program .
my country's current HPV vaccination program .
There are two long-term trials that provide us with a reference by analyzing nonrandomized data from the Costa Rica vaccine trial (bivalent vaccine) and the IARC Indians trial (tetravalent vaccin.
In the Costa Rica vaccine study, about 7,500 women aged 18-25 were randomly assigned to receive the vacci.
The IARC study, which was followed up for a full 10 years, also found that compared with two or three doses, the effect of one dose of the vaccine was not bad, and the immunity to persistent infection was very hi.
Likewise, joint modelling by 4 modelling groups abroad (London School of Hygiene and Tropical Medicine, Public Health England, Laval University, Harvard University) showed that one-dose vaccination has similar health benefits as two-dose vaccination, Even though the first shot may not be effective enough, a two-dose plan is sufficient to provide lifelong protecti.
These data are basically certain, and the latest conclusion of the WHO is reasonable to some exte.
02
02Why is it too urgent: HPV virus and cervical cancer
Why is it too urgent: HPV virus and cervical cancerAs soon as the latest WHO news came out, it immediately caused an upro.
Why is the news that the HPV vaccine only needs one dose to cause so many heated discussions? This also starts from the threat to the life and health of human beings, especially women, from the HPV virus and cervical canc.
Back in time to the winter of 200 On November 15th, the people in the Hong Kong Red Pavilion, Anita Mui, endured the physical and mental devastation caused by illness, and sang the last "Song of the Sunset" on the stage, making it a unique song in her li.
She ultimately failed to defeat the enemy called "cervical cancer", but she brought this enemy into the public e.
Anita Mui sang "Song of the Sunset" for the last time before her death from cervical cancer
Anita Mui sang "Song of the Sunset" for the last time before her death from cervical cancerMore than 30 years ago, human beings first discovered HPV virus in cervical cancer tiss.
Since then, about 15 high genotype HPV (hrHPV) have been confirm.
If persistent infection, it will lead to cervical cancer, precancerous lesions and grade 3 cervical canc.
Intraepithelial neoplasia and adenoma in si.
It can be said that there is a very close connection between HPV virus and cervical canc.
But in fact, although the incidence of cervical cancer is mostly related to cervical infection with HPV virus, infection with HPV virus does not necessarily lead to cervical canc.
The occurrence of cervical cancer caused by HPV virus needs to meet two conditions, one is infection with high-risk HPV virus, and the other is continuous infecti.
There are more than 200 types of HPV viruses, and different types can cause different clinical manifestatio.
According to the different tissue sites that the virus invades, it can be divided into low-risk skin type, high-risk skin type, low-risk mucosal type, and high-risk mucosal ty.
Among them, the low-risk type mainly forms warts on the skin and mucous membranes, while the high-risk type can cause various cancers through persistent infection, including but not limited to cervical cancer, rectal cancer, oral cancer and so .
In 2020, researchers from Sun Yat-sen University School of Public Health and other institutions found that in 2015 in China, a total of 36,714 cancer deaths were attributable to HPV infection, of which 5,170 were male (11% (11.
), 31,544 cases (89%) were female, and the corresponding age-standardized mortality rates were 51/100,000 and 10/100,000, respective.
At present, because there are not enough effective drugs for treatment, we can only prevent it in advance, and the most important way to prevent HPV infection and induce cancer is to inject HPV vaccine in advan.
03
03Vaccine success: Can cervical cancer be completely eliminated?
Vaccine success: Can cervical cancer be completely eliminated?Can we completely eliminate cervical cancer? The answer is almost certainly, but we still have a long way to go to get the.
Last year, the World Health Organization announced that it would eliminate cervical cancer, and China has also actively responded to this ca.
On November 3, 2021, the Lancet, a leading international medical journal, also published a research paper comparing the incidence of cervical cancer and precancerous lesions before and after the start of the free HPV vaccination program in the UK in 200 , the study found, especially in those young women, HPV vaccination led to a sharp decrease in the incidence of cervical cancer and precancerous lesio.
Screenshot of research paper title
Screenshot of research paper titleThe research team assessed diagnostic data on cervical cancer and cervical precancer in women aged 20-64 living in England between 1 January 2006 and 30 June 201 Compared to a reference cohort not vaccinated against HPV, those vaccinated at 12-13 years had an 87% reduction in cervical cancer incidence, those vaccinated at 14-16 years had a 62% reduction, and those vaccinated at 16-18 years decreased by 3
The research team said that the incidence of cervical cancer and cervical precancerous lesions decreased significantly in young women, especially those who were vaccinated at the age of 12-13, following the introduction of the free HPV vaccine programme in the .
The free HPV vaccine program nearly eliminated cervical cancer in women born after September 1, 199
Excerpted from the documentary "American Drugs Under the Undercurrent"
Excerpted from the documentary "American Drugs Under the Undercurrent"These findings point to the benefits of widespread HPV vaccination, but even in developed countries like the UK, where HPV vaccination is available free of charge, coverage is still falling short of the WHO target of 90% for 15-year-old gir.
This also shows that the goal of widespread HPV vaccination and complete elimination of cervical cancer still faces challeng.
At the same time, we need to note that many countries recommend that both men and women receive the HPV vacci.
Because HPV virus not only causes cervical cancer in women, but also causes genital warts, anal cancer and other diseases that can be affected by both men and wom.
HPV6 and HPV11 cause about 90% of genital warts, and HPV16 and HPV18 cause about 70% of cervical and anal cance.
Therefore, the HPV vaccine is not exclusive to women, and everyone needs to pay attenti.
04
04After an overnight hit: HPV vaccine appointments are in trouble
After an overnight hit: HPV vaccine appointments are in troubleBut getting vaccinated should never be a f.
In recent years, the "popularity" of HPV vaccine has its special market background and network effe.
It is precisely because it caters to people's growing gender awareness, the gender-opposed network environment and the needs of capital that it has changed from a marginalized vaccine that has not been paid much attention to to the overnight popularity it is tod.
the he.
Before the HPV vaccine was officially launched in the mainland, many qualified people chose to go to Hong Kong or abroad to be vaccinated, which was understandable under the circumstanc.
However, when the HPV vaccine was approved for marketing in the mainland in 2017, the popularity of going to Hong Kong for HPV vaccine not only did not drop, but instead soared, and the price was also fired to a sky-high price of 10,000 yu.
Today, HPV vaccines, especially nine-valent HPV, are still hard to come.
In some places, appointments have been made for several years without resul.
Even if you queue up at the local health center, you may even have to wait a few more yea.
This sudden heat and abnormal price spike speaks not only to our long-standing neglect of this vaccine, but also to the long-standing deformity of the mark.
Vaccination was originally intended to save lives, but out of stock, purchasing on behalf of others, counterfeiting, fraud, and spreading panic have put the HPV vaccine in troub.
Hopefully this situation will improve in the near futu.
References
References https:// https:// Yong Lu,, et .
, (202
Cancer Attributable to Human Papillomavirus Infection in China: Burden and Tren.
Cancer, DOI: 11002/cn.
3298
, (202
Cancer Attributable to Human Papillomavirus Infection in China: Burden and Tren.
Cancer, DOI: 11002/cn.
3298
The past and present of HPV virus and HPV vaccine - Lilac Garden (d.
cn)
cn)
JCVI interim advice on a one-dose schedule for the routine HPV immunisation programme - G.
UK ( JCVI interim advice on a one-dose schedule for the routine HPV immunisation programme - G.
UK ( One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer (w.
int)
int) leave a message here