The world's first! China reveals the fine structure of the whole virus of the new coronavirus

16, the reporter learned from zhejiang University Medical College affiliated with the first hospital, Zhejiang University Hospital of infectious disease diagnosis and treatment of the national key laboratory Li Lanxuan
task force in cooperation with Tsinghua University School of Life Li Sai researcher team, the first time in the international analysis of the real new coronavirus full virus three-dimensional fine structure, reached an unprecedented resolution, to better understand the biological characteristics of the new coronavirus, vaccine design, antiviral drug research and development is of great significance.
coronavirus is named for its corona-like peripheral corona, a glycoprotein called pyrethroid protein, which is the "key" to the virus's entry into human cells. The study carried out scientific research directly on the virus, and analyzed the natural composition and distribution of the prickly protein on the surface of the new coronavirus.
researchers found that the new coronavirus's prickly protein, like a "chain hammer", can swing freely on the surface of the virus, and that the characteristics of "upper-end coarseness and lower-end fineness" help the virus flexibly "grab" the cell surface, bind to invading cells and infecting the human body. The researchers also found that the new coronavirus hedgehog protein's orientation is hidden - likening the prickly protein to an umbrella, which opens and is called "up", which is like a light weapon, infecting cells, and when the umbrella closes, it is like putting away a weapon to avoid being defeated by body recognition. The new coronavirus prickly protein is 97% down, which is one of the reasons why it is not easily defeated by antibodies and drugs, etc.
In addition, the team pioneered the natural structure and assembly mechanism of the viral cavity kernel KERP complex, which, like beads, organizes ICOs together and arranges them in an orderly manner within the virus, not only solving the problem of receiving more KEROs than it can in a limited space, but also reinforcing the structure of the virus itself so that it can withstand the challenges of the destruction of various physical and chemical factors in complex environments outside the human body, which is an important factor in the long-term survival of the new coronavirus in the external environment.
the genetically engineered vaccines currently being developed are the results of the study of prickly proteins based on in-body recombination expression, is there any difference with the in-place state of the virus? Is the vaccine developed effective against the virus? The team further analyzed the glycosylation composition of the prickly protein through mass spectrometry and found that the glycosylation modification of the prick protein expressed by in-body recombination and the virus in-place state hedgehog protein is highly similar, which is of great guiding significance to the development of inactivated virus vaccine, genetically engineered recombinant vaccine and neutralizing antibody. The findings have been published in the international authoritative journal Cell.