The world's first genetically edited cloned dog ,"Dragon" is completely bred by our country.

How strange would it be when a puppy is genetically edited and cloned into another "self"? Now, Chinese's the first to do it! On the 5th, Beijing Sino Valley Biotech Co., Ltd. officially announced that, by the authority's identification, the company bred big dog "Dragon" and the world's first genetically edited disease model dog "Apple" the same determination odds greater than 99.99 percent, and surrogate dogs excluded parent-child relationship, which proves that "Dragon" is "Apple" cloned dog.
"Dragon" has become China's first fully autonomous breeding sotic cell clone dog, but also the world's first gene editing clone dog.
" marks china's second independent mastery of canine cell cloning technology after South Korea.
," said Lai Liang, a researcher at the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences.
the birth of Dolly, the first sotic-cell cloned sheep, humans cloned mice, cattle, goats, pigs and other mammals, but the cloned dog was slow to make it.
is widely regarded by the scientific community as one of the most difficult animals to clone because of bottlenecks in canine cell cloning technology, which has long been monopolized by South Korea.
Lai led the company's research team, using the latest gene-editing technology CRISPR/Cas9, knocked out the dog's APOE gene, elevated its plasma cholesterol, induced its atherosclerosis lesions, and successfully bred the world's first model atherosclerosis disease dog "Apple."
, the researchers bred "Apple" cloned dogs, and by optimizing the technology platform, improve the bed-ded efficiency and pregnancy rate of cloned embryos.
the popular explanation for this process is that people edit a dog's genes, "customize" its function, and then copy it as a template for "mass" production.
this is the first time in our country and in the world.
" China has bred gene-editing monkeys, gene-editing dogs.
china is at the forefront of the world in the preparation of models of large animal diseases.
" Lai Liangxuan introduced, cloning dog technology breakthrough, people can be as needed to carry out functional "customization", such as a one-time breeding of a number of genetic background, similar age experimental dogs, used to study the occurrence of disease and verify the efficacy of new drugs; Knocking out or knocking into a dog's genes makes the dog more sensitive and muscular, making it a good police dog or search-and-rescue dog and other working dogs, and can replicate the same dog after the dog's death, allowing the owner's feelings to continue.
, co-founder of Chino Valley, revealed that a second surrogate dog has now had two more "apple" clones and has been identified as DNA homogeneity.
they will also develop model dogs and functional gene-editing dogs for a variety of diseases, including autism, to promote the commercialization of dog cloning technology.
(Chen Lei)