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    Home > Biochemistry News > Biotechnology News > The world's first high-definition analysis of the complete dynamic process of the homecoming of hematopoietic stem cells in the body.

    The world's first high-definition analysis of the complete dynamic process of the homecoming of hematopoietic stem cells in the body.

    • Last Update: 2020-08-06
    • Source: Internet
    • Author: User
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    Pan Weijun, a researcher at the Shanghai Institute of Nutrition and Health research of the Chinese Academy of Sciences, led his research team to analyze for the first time in the world the complete dynamic process of the homecoming of hematopoietic stem cells in the world, and the results were published online on November 20, Beijing time, in the international academic journal Nature.
    hematopoietic stem cells can produce all types of blood cells in the body by proliferation differentiation, while hematopoietic stem cells can self-renew and differentiate downstream to establish the entire blood system by "homecoming" to hematopoietic tissue.
    "homecoming" usually refers to the life process in which a particular cell group in a circulatory system is directed to the biological tissue or organ microenvironment, maintaining or reshaping the fate of its cells.
    the concept of hematopoietic stem cells to return to nest has a long history, based on their ability to return to the nest of hematopoietic stem cell transplantation has been widely used in clinical treatment of major diseases such as blood, immunity and tumor.
    but because the space-time span of the life process is very large, the means of observation are very limited.
    Although the researchers in the past few decades of research process, the return of cells and molecular basis of a certain analysis, but the return of the nest in the physiological situation of how to occur, the microenvironment of the nest is what kind of structure, micro-environment cells and how to help hematopoietic stem cells home, such as a series of key scientific principles are still very little, seriously restricting the development of clinical hematopoietic stem cell transplantation and other related technologies.
    Figure 1: Three-dimensional reconstruction model of hematopoietic stem cells returning to the "hot spot area" (red for hematopoietic stem cells, blue for arteries, green for veins) Figure 2: "Pilot cells" guide hematopoietic stem cells into the vascular microenvironment (purple cells are "pilot cells", VC indicates intravenous microvascular, green Representing vasculars) In order to overcome this scientific and technological problem, Pan Led his team for 6 years, on the basis of optimizing the living imaging technology, to further integrate the active immunofluoriate markers, genetic regulation and graphic reconstruction calculation methods, the first set of a new set of complete analysis of the whole process of internal hematopoietic stem cells home.
    researchers in the world to use color-changing fluorescent protein to establish a hematopoietic stem cell marker system, under the high-resolution confocal fluorescence microscope, the establishment of hematopoietic stem cell long-range living observation tracking program, from macro to micro, vividly presented the hematopoietic stem cells from birth to home.
    , after the statistical analysis of large-scale long-range living imaging, the space-time law and "hot spot region" of hematopoietic stem cells were found, and combined with fine imaging and 3D reconstruction techniques revealed the unique microvascular structure of the natural environment of the nesting environment of hematopoietic stem cells.
    , they also accidentally discovered a new microenvironment cell and named it "pilot cell."
    these cells are a previously undefined new subtype of macrophages that exist near the "hot spots" of the nest, and they can identify hematopoietic stem cells that enter hematopoietic tissue and introduce them into specific vascular structures, thus enabling the homecoming of hematopoietic stem cells.
    this is an original scientific discovery independently completed by Chinese scientists, and the research process breaks through the existing theory and research system, and presents the whole process of hematopoietic stem cells returning to the nest in an organism from a unique perspective.
    has opened a new era of long-range, high-resolution research in the field of hematopoietic stem cells in the world.
    the work not only answers the important scientific question of "how the hematopoietic stem cell returns to the body" which occurs in the field of world hematopoietic stem cell research, but also discovers the "pilot cell" which plays a key guiding role in the return of hematopoietic stem cells, and puts forward a new theory and creates a new idea for the transformation of the conversion to improve the efficiency of hematopoietic stem cell transplantation.
    the above-mentioned research results were led by Pan Yujun graduate students Li Danxuan, Xue Wenzhi and Li Mei, and li Lin, Chen Jianfeng, Zhou Bo, researcher of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, Yao Xuexuan, professor of Science and Technology University of China, And Wu Tianqing, a professor at Yale University School of Medicine, and was jointly completed, with the help of Luo Lingfei, a professor at Southwest University, and Wen Zilong, a professor at the University of Science and Technology of Hong Kong.
    this achievement is supported by the Chinese Academy of Sciences" molecular basis and regulation of cell destiny molecular basis and control" strategic pilot plan and equipment development plan, ministry of Science and Technology national key research and development plan, the National Natural Science Foundation project, Shanghai Science and Technology Commission basic key projects and so on.
    Source: Shanghai Institute of Nutrition and Health.
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