The world's first pig kidney transplantation human body operation completed gene editing and exerted efforts to cultivate high-quality humanized donor pigs

Recently, scientists from the New York University Langone Medical Center transplanted a genetically edited pig kidney to a human for the first time.

Genetically modified pig kidney to avoid rejection

The performance of pigs in terms of physiology, anatomy, organ size, etc.

In June last year, China's first medical mini-pig production, research, and breeding base settled in the Neijiang National Agricultural Science and Technology Park in Sichuan, dedicated to the breeding, research, and application transformation of domestic medical pigs and organ transplant donor gene-edited mini-pigs

"Xenotransplantation has always had two major problems to be solved, one is the problem of immune rejection, and the other is the problem of biosafety

“Xenogeneic kidney transplantation cannot always stay in pre-clinical trials.

In this study by American scientists, the subject was a female brain-dead patient who showed signs of renal insufficiency before surgery

Because the transplanted pig kidney was genetically modified, the operation did not immediately cause rejection

According to reports, in xenotransplantation, α-galactose is the main cause of hyperacute immune rejection

"This human trial only verified that the gene-edited pigs overcome the hyperacute rejection of xenotransplantation.

my country is working hard to breed high-quality donor pigs

All along, the world has faced a shortage of human organ transplants

"The strategies to solve the shortage of donor organs include organ donation, artificial organs, and xenogeneic organ transplantation

Over the years, the United States has carried out a number of preclinical trials of xenotransplantation, and the results of preclinical trials of pig kidney have been at the international leading level

In 2010, Pandengke's team obtained the first donor pig in China that knocked out genes such as α1 and 3GT to overcome hyperacute rejection