The world's first somatic cell cloned monkey birth: China and china" and "Huahua" came!

Take root of your sweat and blow your breath, and you'll be able to turn out a bunch of little monkeys.
now, "Qi Tianda Saint" Sun Wukong's life, really become a reality.
recently, two macaque babies born on the non-human primate research platform of the Institute of Neuroscience of the Chinese Academy of Sciences "germinated" everyone, laughing and playing together from time to time, and sometimes snuggling up to their beloved "Hello Kitty" plush toy, staring at the world with big eyes and curiously.
the "parents" of the two little monkeys, the Institute of Neuroscience of the Chinese Academy of Sciences, the Center for Excellence in Brain Science and Intelligent Technology research team.
after five years of unremitting efforts, they have achieved the first non-human primate somatic cell cloning in the international community.
The results were published in a cover article in the January 25 issue of Cell magazine, published online on January 25.
the two little guys named "China" and "Huahua" also became the world's most precious pair of macaques overnight. Why is it so hard to clone monkeys
? Since the success of the successful cloning of dolly sheep somatic cells in 1997, humans have opened a new window.
20 years, many mammals have been successful in the cloning of somatic cells, not only the birth of horses, cattle, sheep, pigs and camels and other large livestock, but also the birth of mice, rats, rabbits, cats and other experimental animals.
however, the cloning of somatic cells of non-human primates, which are closest to humans, has not been solved and become seiswells around the world.
the United States, China, Germany, Japan, Singapore and South Korea and other scientific research institutions in this area of continuous exploration and experiment, but has not been successful.
" one of the main limiting factors is incomplete reprogramming of donor nuclei in the receptor oocytes, resulting in low embryonic development rates. "In addition, the operation techniques of non-human primate embryos are not perfect, which has affected the success of the experiment, " said Sun Qiang, author of the
" article and director of the non-human primate research platform at the Institute of Neuroscience of the Chinese Academy of Sciences.
" a necessary step in embryo manipulation is to denuclearize the oocytes.
but unlike other animals, monkeyoocs are opaque, making denuclearoperation very difficult.
researchers have come up with a way to "light" cells using polarized light, but in order to minimize the impact on cells, the operation must be done in a very short time.
to this end, the first author of the article, the Institute of Neuroscience of the Chinese Academy of Sciences non-human primate research platform postdoctoral Liu Zhen spent a lot of time to train this technology, and finally achieved the precise completion of the micro-operation of somatic cell nuclear transplantation in 10 seconds. At the same time, the
, the researchers continue to try various experimental methods, through epigenetic modification to promote the reprogramming of somatic cell nucleonuclear, significantly improve the body cell cloned embryo sac quality and the pregnancy rate of surrogate monkeys.
November 27, 2017, the world's first individual cell cloning monkey "Middle China" in the Chinese Academy of Sciences Institute of Neuroscience, Brain Science and Intelligent Technology Center for Excellence innovation in the birth of a non-human primate platform;
the really useful animal model cell cloning monkey is in the Chinese Academy of Sciences strategic pilot science and technology special "brain function joint map and brain-like intelligence research" support, completely completely completed by the Chinese Academy of Sciences team independently of the international breakthrough.
" This achievement is a real achievement of corner overtaking in the life sciences field, which is of great significance.
Bai Chunli, president of the Chinese Academy of Sciences, said the results marked the first china to open a new era of somatic cell cloning monkeys as an experimental animal model, and realized China's transformation from international "and running" to "leading" in the field of non-human primate research.
the success of somatic cell cloning monkeys, adding "new members" to the animal model family.
currently, the animal model common to drug development is mice.
but mice are far from humans, drug developers spend a lot of money on mouse models, but the candidate drugs screened for use in patients are largely ineffective or have unacceptable side effects, which make it impossible to get effective treatment for brain diseases such as Alzheimer's disease, autism, and immunodeficiency, tumors, metabolic diseases, etc.
makes non-human primate models urgently needed for life science research and human disease research.
therefore, in addition to the significance of basic research, the use of somatic cell cloning technology to make a model monkey of brain disease, for human society to face the mechanism of the mechanism of research, intervention, diagnosis and treatment has brought unprecedented bright prospects.
" this result makes macaques potentially a truly useful animal model.
" said Pu Muming, a member of the Chinese Academy of Sciences, a member of the Chinese Academy of Sciences, director of the Institute of Neuroscience of the Chinese Academy of Sciences, and director of the Center for Brain Intelligence Excellence.
Bai Chunli also believes that the success of somatic cell cloning monkeys, as well as the future creation of somatic cell-based cloned monkey disease model, will effectively shorten the drug research and development cycle, improve the success rate of drug research and development, so that China will take the lead in the development of non-human primate animal model of the new pharmaceutical research and development industry chain, a strong impetus to China's new drug creation and research and development, to help "healthy China 2030" goal to achieve.
ethical questions? It doesn't exist! Two little monkeys are now living in the lab healthy and lively, but people's questions follow: the cloned monkey sit out, clones will be far away? In response to this high public concern, Pu Muming made it clear that the Purpose of the Chinese Academy of Sciences is not to clone human beings, but to improve human health and to study basic issues in brain science.
, on the contrary, the work could also resolve some ethical disputes.
At present, China exports tens of thousands of macaques a year, mainly for drug screening.
in Pu Muming's view, such a large number of animal experiments, in the ethical aspects of the problem. "We're doing this to solve this ethical problem,"
.
"With somatic cell cloning monkey technology, people can use somatic cells in vitro to effectively do gene editing, accurately screen genotype same-body cells, produce a large number of embryos with identical genotypes, with the mother monkey carrier pregnant to give birth to a number of gene editing and genetic background of the same group of monkeys."
this is that the institute of neuroscience in the Chinese Academy of Sciences, the chinese Academy of Sciences institute of this technology, allowing people in a year to prepare a large number of genetic background of the same model monkeys, greatly reducing individual differences on the interference of the experiment.
so that a very effective screening can be done with a small number of cloned monkeys.
"Any scientific discovery is a double-edged sword that can lead to significant progress and a series of crises, as is the case with nuclear energy and gene editing," he said.
", in Pu Muming's view, the ethical issue of life science is not only needed by scientists to pay attention to, but also requires the participation of government departments and the general public as a whole, through regulations, legislation and other ways to restrain people's behavior and make the right decisions.
" we should pay attention to new technologies, but don't be afraid.
," he added.
.