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    Home > Active Ingredient News > Infection > The world's largest new crown autopsy results reveal: the new crown is the root cause of death in 86% of autopsy cases

    The world's largest new crown autopsy results reveal: the new crown is the root cause of death in 86% of autopsy cases

    • Last Update: 2022-04-29
    • Source: Internet
    • Author: User
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    According to the latest data from WHO, as of March 21, 2022, there were 470,839,745 confirmed cases of COVID-19 worldwide and 6,092,933 deaths
    .

    Divided by land plate, the Americas have the most deaths, followed by Europe and Southeast Asia; by country, the United States, Brazil and India have 964,473, 657,205 and 516,543 deaths, respectively
    .

    Figure 1 As of March 21, global new crown death data (Source: [1]) The death caused by the new crown has always been the focus of medical research, so how should "new crown death" be defined? Among infected people, what is the proportion of people who die directly from the new coronavirus? Please follow the latest German new crown autopsy study to find out
    .

    First, we need to clarify what "corona death" is
    .

    The World Health Organization (WHO) once defined "unless there is confirmed other cause (such as severe trauma) that is clearly not related to the new crown, a new crown death is a suspected or confirmed new crown case.
    Death caused by a clinically relevant disease" [ 1]
    .

    The Office for National Statistics (ONS) of the United Kingdom defines it as "death caused by the new crown determined by a doctor except for a positive nucleic acid test" [2]
    .

    Autopsy is an important method in the medical field to analyze the cause of death of patients.
    Medical researchers from all over the world have also been working on autopsy to find out the direct connection between the new coronavirus and death.
    There is no shortage of related new coronavirus autopsy studies, but most of them are conducted by a single center.
    of small to medium cohort studies, so the results are not representative
    .

    In April 2020, Germany launched an autopsy registry for COVID-19, dedicated to collecting COVID-19 autopsy samples and studying multicenter autopsy data to report relevant data to policymakers, professional associations, and the public
    .

    In February 2022, the research team of the RWTH Aachen Medical School in Germany released the first autopsy report on the death case of the new crown in Germany, which was published online on The Lancet Regional Health-Europe under the title "First report from the German COVID-19 autopsy registry" (Fig.
    2), this study is currently the largest autopsy study of the new crown in the world
    .

    Figure 2 Research results (Source: [3]) The research team of the RWTH Aachen Medical School in Germany conducted autopsies on 1,129 COVID-19-related deaths collected from all over Germany, focusing on analyzing the effects on the pulmonary vasculature or nervous system, Systemic viral transmission or interaction with the immune system to further explore the direct relationship between COVID-19 and death
    .

    The main results of this study are as follows: 1.
    Most cases died within 2 weeks after infection
    .

    The sample of this study was 1129 autopsy cases, and the time interval between the first occurrence of new crown symptoms (or positive new crown virus test) and death in most of the deaths was less than 2 weeks (median 2 weeks, interquartile range 2.
    6 weeks), The time interval from the first appearance of new crown symptoms to death in more than one third of the cases was between 2 and 5 weeks, and more than one tenth of the cases died more than 5 weeks after the first infection with the new crown, as shown in the following figure (Figure 3): Figure 3 The time interval from the first appearance of new crown symptoms to death (Source: [3]) Second, the peak age of death is different for men and women
    .

    The male-to-female ratio of the sample in this study was 1.
    8:1, and the study found that male deaths from COVID-19 peaked in the 65-69 and 80-84 age groups, while females peaked in the age group over 85 (Figure 4)
    .

    This data further confirms that older people are at greater risk of death after contracting the new crown
    .

    Figure 4 Differences in the age of death between the sexes during the three waves of different mutant strains in Germany (Source: [3]) Third, the new crown is the underlying cause of death in 86% of autopsy cases
    .

    Analysis of the chain of events leading directly to death showed that in 86.
    2% of the autopsy cases (Figure 5), the most common lethal diseases among the underlying causes of death from COVID-19 were diffuse alveolar damage (DAD) and acute respiratory distress syndrome (ARDS).
    ), accounting for 52.
    5% of all cases, followed by multiple organ failure, accounting for 18%; pulmonary bacterial superinfection, accounting for 5.
    7%; pulmonary embolism, accounting for 4.
    0%,
    etc.

    In the remaining 14% of autopsy cases, COVID-19 was a concomitant disease
    .

    Stratification of cause of death by sex showed that the distribution of cause of death diagnoses was similar, with no significant differences between male and female deaths
    .

    Figure 5 Causes of death of autopsy cases (Source: [3]) Although this study did not include the death of the Omicron variant, this large-scale autopsy report will help researchers to better understand the new crown The pathological and physiological characteristics of the virus provide a theoretical basis for the treatment of the new crown, and still have certain reference significance
    .

    Here, the editor warmly reminds that the new crown virus is not a big flu.
    For the unvaccinated people, especially the elderly, the new crown virus still poses a huge threat
    .

    Source of the title map: T21RS, only for academic exchange
    .

    Written | Luna Typesetting | Text Competition EndReferences: [1]https://covid19.
    who.
    int/[2]https://
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