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Recently, Zhang Xin Of the Strong Magnetic Field Science Center of Hefei Institute of Material Sciences of the Chinese Academy of Sciences, in cooperation with the Lu Light Uranium Research Group and Timothy Mitchison of Harvard Medical School, used the water-cooled magnet No. 4 of the Large Science Device of the Strong Magnetic Field Science Center to discover for the first time that 27T strong stable magnetic field can significantly change the direction and morphology of the distribution of silk-splitting spindles in human cells.
study was published online in the international journal eLife under the title 27 T Ultra-high Static Magnetic Field Changes Orientation and Morphology of Mitotic Spindles in Human Cells.
cell silk division is the process by which progenitor cells distribute genetic material and other genetic material to two child cells precisely and evenly, and is a key step in determining the fate of cells, which is essential for maintaining the normal physiological function of cells and the growth and development of organisms.
silk-splitting spindle is a special cell device formed by cells in the process of silk-splitting, and is accompanied by a process of silk-splitting and highly dynamic changes, thus regulating the correct arrangement and separation of chromosomes.
, its correct assembly and orientation determine the accuracy of the silk splitting process in time and space.
and micro-tube protein is the main component of the silk split spindle body, its assembly and assembly determines the shape of the entire spindle body.
current research shows that purified micro tubes can be arranged neatly under medium- and high-intensity magnetic fields, and the effect of arrangement is significantly positively related to magnetic field strength.
that microcontrotes are important targets for magnetic fields to divide spindles, but there has been a lack of experimental validation of cellular levels.
, due to the limitations of magnet conditions and so on, the current international study of biological samples under a steady-state magnetic field up to 17T, and 20T or more of biological effects research is still blank. The
Zhang Xin Task Force and the Lu Light Uranium Task Force, relying on the large scientific device of the Strong Magnetic Field Science Center, initially established a biological sample incubation system that can be applied to different magnets, and, in cooperation with Mitchison of Harvard Medical School, studied the distribution direction and morphological changes of the spindle spindles using human nasopharyngeal cancer cells (CNE-2Z) and human retinal epithelial cells (RPE1) under a steady-state uniform strong magnetic field of 27T.
results show that the magnetic moment generated by the 27T steady-state strong magnetic field can change the shape of the spindle body by acting on the micro-tube, and at the same time, the direction of the spindle body is determined by affecting the micro-tube and chromosome.
, the arrangement of chromosomes dominates the orientation effect of a steady-state magnetic field on the spindle body, and whether it is neatly arranged on the equatorial plate during the split period ultimately determines the direction of the spindle body.
the research results can not only provide reference for exploring the role of silk-splitting spindles in developmental biology, including cell fate and tissue structure, but also lay the foundation for the study of the role of cytosilos and silk-splitting in tumor biology.
the study was supported by the 100-person program of the Chinese Academy of Sciences and the National Natural Science Foundation's Joint Fund for Large Scientific Installations.
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