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    Home > Active Ingredient News > Antitumor Therapy > Ther Adv Med Oncol: Real-World Data Study of Treatment and Prognosis in Young (≤40 Years) Patients with Newly Diagnosed Metastatic Female Breast Cancer

    Ther Adv Med Oncol: Real-World Data Study of Treatment and Prognosis in Young (≤40 Years) Patients with Newly Diagnosed Metastatic Female Breast Cancer

    • Last Update: 2022-02-20
    • Source: Internet
    • Author: User
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    Recently, a French study was published in the journal Therapeutic Advances in Medical Oncology to explore the management and prognosis of young (≥40 years old) women with newly diagnosed metastatic breast cancer in the real world .


    Recently, a French study was published in the journal Therapeutic Advances in Medical Oncology to explore the management and prognosis of young (≥40 years old) women with newly diagnosed metastatic breast cancer in the real world .


    The study evaluated data on 22,463 40-year-old women with newly diagnosed MBC treated between 2008 and 2016 (NCT0327531)


    The study evaluated data on 22,463 40-year-old women with newly diagnosed MBC treated between 2008 and 2016 (NCT0327531)


    4524 patients met the inclusion criteria, of whom 598 (13%) were ≤40 years old


    Among HR+/HER2– patients, the majority (89.



    first-line treatment

    With a median follow-up of 49.


    With a median follow-up of 49.



    OS and PFS


     OS



    In univariate analysis, younger age, HR+/HER2 and HER2+ subtype, low grade (I/II vs .


    The median PFS1 was 14.



     PFS

    In the entire population, 96 patients had BRCA1/2 mutations, 44 of whom were ≤40 years of age
    .
    Grade III tumors were more common in younger BRCA patients (63.
    4%, vs 49% in the overall population)
    .
    Most patients had HR+/HER2- and TNBC tumors (52.
    3% and 43.
    2%, respectively), and only 2 (4.
    5%) patients had HER2+ tumors
    .
    Compared with older BRCA patients, younger BRCA women had fewer HR+/HER2- tumors (52.
    3% vs 71.
    2%) and more TNBC tumors (43.
    2% vs 17.
    3%)
    .
    Older women with BRCA had more bone metastases than younger women (73.
    1% vs 43.
    2%, p = 0.
    0030)
    .
    The vast majority of young and older women with BRCA received CT as first-line therapy (97.
    7% vs 86.
    5%, p = 0.
    07)
    .

    In the entire population, 96 patients had BRCA1/2 mutations, 44 of whom were ≤40 years of age
    .
    Grade III tumors were more common in younger BRCA patients (63.
    4%, vs 49% in the overall population)
    .
    Most patients had HR+/HER2- and TNBC tumors (52.
    3% and 43.
    2%, respectively), and only 2 (4.
    5%) patients had HER2+ tumors
    .
    Compared with older BRCA patients, younger BRCA women had fewer HR+/HER2- tumors (52.
    3% vs 71.
    2%) and more TNBC tumors (43.
    2% vs 17.
    3%)
    .
    Older women with BRCA had more bone metastases than younger women (73.
    1% vs 43.
    2%, p = 0.
    0030)
    .
    The vast majority of young and older women with BRCA received CT as first-line therapy (97.
    7% vs 86.
    5%, p = 0.
    07)
    .

    In conclusion, the study showed that among patients with newly diagnosed metastatic breast cancer, the median OS of younger patients (≤40 years old) was better than that of patients aged 41-69 years
    .
    The prognosis of patients with different subtypes varies greatly, which deserves further study
    .

    In conclusion, the study showed that among patients with newly diagnosed metastatic breast cancer, the median OS of younger patients (≤40 years old) was better than that of patients aged 41-69 years
    .
    The prognosis of patients with different subtypes varies greatly, which deserves further study
    .
    Studies have shown that among patients with newly diagnosed metastatic breast cancer, younger patients (≤40 years) have a better median OS than patients aged 41-69 years
    .
    The prognosis of patients with different subtypes varies greatly, which deserves further study
    .
    Studies have shown that among patients with newly diagnosed metastatic breast cancer, younger patients (≤40 years) have a better median OS than patients aged 41-69 years
    .
    The prognosis of patients with different subtypes varies greatly, which deserves further study
    .

    Original source:

    Original source:

    Amélie Mallet, Amélie Lusque, Christelle Levy, et al.
    Real-world evidence of the management and prognosis of young women (⩽40 years) with de novo metastatic breast cancer.
    Ther Adv Med Oncol.
    2022, Vol.
    14: 1-15 .
    DOI: 10.
    1177/17588359211070362.

    Amélie Mallet, Amélie Lusque, Christelle Levy, et al.
    Real-world evidence of the management and prognosis of young women (⩽40 years) with de novo metastatic breast cancer.
    Ther Adv Med Oncol.
    2022, Vol.
    14: 1-15 .
    DOI: 10.
    1177/17588359211070362.


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