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    Home > Chemicals Industry > Chemical Technology > There is a new method for the synthesis of non-steroidal anti-inflammatory drug precursors

    There is a new method for the synthesis of non-steroidal anti-inflammatory drug precursors

    • Last Update: 2022-03-02
    • Source: Internet
    • Author: User
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    A few days ago, the research group of Professor Mao Jianyou of Nanjing University of Technology developed a method for the synergistic catalysis of photocatalysts and transition metal catalysts


    Using dihydropyridine as reducing agent, the research group developed a three-component asymmetric reductive cross-coupling reaction with mild conditions, wide range of raw materials and excellent enantioselectivity by using photocatalyst and nickel catalyst synergistic catalysis strategy.


    Chiral α-arylpropionic acids are an important branch in the family of anti-inflammatory drugs, and naproxen, ibuprofen, flurbiprofen, etc.


    "Although there are many traditional synthesis methods for α-arylpropionic acid compounds, some of these methods are cumbersome, labor-intensive, and costly, and some have less suitable raw materials and unsafe reactions


    "The raw materials of the method we used are simple and easy to obtain, easy to operate, and the photocatalyst and the base used in the reaction can also be recycled and reused


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