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Introduction: Research shows that the new small molecule compound Me6TREN is expected to develop into a candidate for the treatment of acute enteric radiation disease.
13, 2020, the international academic journal Theranostics published online the latest research results from the Military Medical Research Institute of the Academy of Military Sciences and the South China Stem Cell and Regenerative Medicine Research Center, "Me6TREN targets beta-catenin signaling to the resuring cell regeneration radiation".
Yu Xuetao and Professor Li Yanhua are co-authors of the article, and Dr. Wang Sihan is the first author.
The paper found that the new small molecule compound Me6TREN (Me6) has the effect of promoting post-radiation repair of intestinal endocrine cells, and that the compound can regulate the regeneration of intestinal stem cells by activating the ERK/AKT-beta-catenin signaling pathracyte, thereby significantly improving the survival of the mouse model of enteropathic radiation disease.
stem cell technology to promote the regeneration and repair of damaged tissue is one of the research team's key research directions.
, based on a stem cell technology platform, the team screened and discovered that the new small molecule compound Me6 has the function of mobilizing hematopoietic stem/progenior cells and endothorte progenitocytes in the bone marrow and promotes angiogenesia in the ished lower extremities (the results of the study were published in the international academic journal Blod, 2014; Scientific Reports, 2014).
they speculate that the compound may have the effect of promoting the regeneration and repair of radiation damage tissue.
In this study, researchers found that the small molecular compound Me6 significantly reduced intestinal endoskin cell damage caused by ionizing radiation, promoted its repair, and significantly improved survival in mice exposed to large doses of radiation throughout the body or abdomen.
compound Me6 can activate the regenerative function of intestinal stem cells in damaged intestinal tissue and promote the production of new hidden nests in the intestinal cortical cortical, and based on mouse small intestine organ models, it is further found that small molecular compound Me6 can promote the growth of small intestine organs under normal culture conditions, improve the proportion of Lgr5 plus small intestine stem cells, suggesting that the compound can be used as a new addition to intrabodic culture amplification of intestinal organs.
, compound Me6 further demonstrated the role of promoting regeneration after radiation damage to the intestinal organs.
further studies have found that Me6 regulates the regenerative function of intestinal stem cells by activating the ERK/AKT-beta-catenin signaling path.
Notable, the researchers found that the compound Me6 had no significant effect on the growth of tumor tissue formed by HCT116 cells in the body, suggesting that the compound has potential for clinical conversion and could be used to prevent or treat acute enteropathic diseases caused by radiotherapy of tumors, such as radioactive enteritis or sudden nuclear accidents.
, based on the intestinal organ model and the abdominal/systemic irradiation model, the researchers confirmed that the small molecular compound Me6 can promote the repair of intestinal cortectal cells by activating the regenerative function of intestinal stem cells and improve the survival of irradiated mouse models.
results will lay the foundation for the future development of new drugs for the treatment of acute bowel radiation disease.
original source: 1. Wang S, et al. Me6TREN targets beta-catenin signaling to inspire intestinal stem cell regeneration after radiation. Theranostics, 2020; 10(22): 10171-10185. doi:10.7150/thno.46415. Available from 2. Zhang J, et al. Smallmoor Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis. Blood. 2014; 123(3): 428-441. doi:10.1182/blood-2013-04-4985353. Chen H, et al. A novel products Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell force and search. Sci Rep. 2014; 4: 6222. doi: 10.1038/srep06222.