These are both calcium ion antagonists, what's the difference?

Guide: How do calcium ions affect high blood pressure? The pharmacist had a friend who had just been diagnosed with high blood pressure and was exposed to a very academic term called "calcium ion antagonists", and he found that the high blood pressure drugs he and his family were taking happened to be of this type, one was ammonia chloride and the other was nitrobenzene, two drugs with similar names that caught his attention.
pharmacist prepared to take a careful chat, these two are the same as the "ground flat" character of the drug, the difference is.
first, let's explain what "calcium ion antagonists" are.
also known as calcium ion antagonists, or calcium channel blockers.
a class of antihypertensive drugs developed in the 1960s.
the chemical structure of different calcium channel blockers is very different, and the pharmacological effects are not the same.
With the increasing number of calcium channel blockers, the World Health Organization (WHO) has classified calcium antagonists as selective and non-selective calcium channel blockers, and further subdivided into six sub-categories according to their chemical structure and pharmacological effects, the family is very large.
the ammonia chlorine and nitrobenzene, which are to be talked about today, belong to one of the categories of selective calcium channel blockers, which are dihydrogen.
"functions" and "responsibilities" are relatively similar, the differences of course exist, below we are divided into the following four points to explain.
01, the body's role time and duration are different which is the biggest difference between the two.
Dihydrocarbon calcium ion antagonist antihydrotespressants are divided into two main categories of long-acting drugs and short-acting drugs according to the time and duration of the drug's effect in the body, and "ammonia chlorpyrene" and "nitrobenzene", which are the representatives of these two types of drugs.
chlorpyrepin is a long-acting calcium ion antagonist.
After taking, the peak time of the drug (i.e. the time when the drug reaches the maximum concentration of blood drugs in the body) is 6 to 12 hours, the half-life of the drug (i.e. the time it takes for the concentration of the drug in the blood to be reduced by half) is 35 to 50 hours, so for ammonia chlorpyrone, generally made into ordinary tablets can be made, take one tablet a day, you can achieve the effect of continuous blood pressure reduction.
nitrobenzene is a short-acting calcium ion antagonist.
After taking, the peak time of the drug is 1 to 2 hours, the half-life of the drug is 2.5 to 3 hours, oral regular release agent type of nitrobenzene (such as nitrobenzene tablets), should be taken at least 2 times a day, in order to achieve the effect of blood pressure reduction.
There is also a class on the market is nitrobenzene flat-controlled release preparations, these tablets through the process of special drug preparations, can let the drug slowly release in the body, so that the peak time of the drug also reached 6 to 12 hours, once a day can be taken.
for nitrobenzene, it is recommended to choose slow release tablets or controlled release tablets to take, smooth control of blood pressure at the same time, once a day, can better improve the compliance of medication.
02, the adaptive disorder is not exactly the same in addition to high blood pressure, these two drugs can also cure what? The selectivity effect of ammonia chloride level on vascular smooth muscle is greater than nitrobenzene, it can expand the outer artery, directly act on the vascular smooth muscle, reduce the external vascular resistance, so, more suitable for chronic stability angina and variant angina.
Nitrobenzene focuses on dilating the coronary arteries, especially the large blood vessels, can effectively reduce the tension of the coronary artery smooth muscle, prevent vascular spasms, increase blood flow of narrow blood vessels, improve oxygen supply, while dilating the surrounding small arteries, reduce peripheral resistance, so that blood pressure drops.
small doses of nitrobenzene do not affect the heartbeat when dilating the coronary artery, so it can be applied to coronary heart disease (tired angina).
03, different representative foods interact with food/drug: grapefruit/grapefruit juice grapefruit juice inhibits the cytochrome P4503A4 system.
chlorpyrium and grapefruit juice can be said to be safe under the existing research.
nitrobenzene and grapefruit juice, can make nitrobenzene blood drug concentration increase and extend its action time, thereby enhancing the role of pressure reduction.
who regularly take grapefruit juice, the effect can last for at least 3 days after the last dose.
therefore avoid grapefruit/grapefruit juice if taking nitrobenzene.
representative drug: dygosin chlorpyrus and tyrosin co-use did not change the normal volunteer plasma level or the removal rate of the kidneys.
but the simultaneous use of nitrobenzene and tygoxin will lead to a decrease in the removal rate of tygoxin, increasing the concentration of tygoxin blood medicine.
should therefore monitor their blood drug concentrations to prevent drug overdoses and, if necessary, reduce their dosages according to the concentration of high-sing blood drugs.
04, special population application range of women during pregnancy: First of all, it should be noted that there is currently no antihypertensive drug for pregnancy hypertension / hypertension combined pregnancy patients are absolutely safe.
of nitrobenzene and nitrobenzene flattening tablets can be used under physician's weighing.
and ammonia chloride leveling lack the corresponding research data on pregnant women, generally not selected.
elderly patients: the common tablets of nitrobenzene can easily cause low blood pressure in elderly patients, and the risk of myocardial infarction and stroke increased, generally not selected, elderly patients can nitrobenzene flat release tablets.
common dosage form of ammonia chloride leveling can be used more safely in the elderly.
summary there is no perfect anti-pressure medicine, only more suitable for their own anti-pressure drugs.
medicine choice of tens of millions, safety first, so should be combined with their own situation and disease status, consult a doctor or pharmacist, in order to better control the disease, improve the quality of life.
References: Guidelines for the Rational Use of Hypertension (Version 2), 2017 (2017) Guidelines for the Diagnosis and Treatment of Coronary Heart Disease (2018)