These studies tell you! Drinking is really bad for your health!

In this article, Xiaobian collated a number of research reports, let's take a look at the harm of drinking on the body health! Share with you! Photo source: syani Mukherjee / Rutgers University New Brunswick [1] Acer: Alert! Moderate to severe drinking during pregnancy may change the gene expression of fetal body doi: 10.1111/acer.14148 Recently, a research report published in the international journal Alcoholism: clinical and experimental research shows that moderate to heavy drinking during pregnancy may change the expression of fetal body DNA Professor Dipak K Sarkar, researcher, said that in this study, we can easily detect the prenatal exposure of fetus to alcohol, and also help us to develop early interventions to improve their health In this study, researchers found that alcohol induced DNA changes in 30 pregnant women and 359 children The researchers found two gene changes in pregnant women who drank moderate to large amounts of alcohol and children who were exposed to alcohol in the fetal period, namely POMC gene and per2 gene POMC gene can regulate the body's stress response system, while per2 gene can affect the body's biological clock Female alcohol drinking refers to drinking at least 4 cups in at least 5 drinking events each month, while moderate alcohol drinking refers to drinking at least 4 cups in at least 5 drinking events each month Drinking is defined as about three drinks per drink Our findings may help scientists predict the risk of prenatal exposure to alcohol with specific biomarkers, said researcher Sarkar 【2】 Enouro: excessive drinking can inhibit brain development of teenagers doi: 10.1523/eneuro.0044-19.2019 a new study shows that large use of alcohol by teenagers is not only dangerous in itself, but also slows down the growth rate of developing brain According to a recent study published in the Journal eneuro, heavy drinking can slow down the growth rate of the brain every year In the case of humans, it's equivalent to four beers a day Chronic alcoholism reduced the growth rate of the brain, white matter and cortical hypothalamus Researchers measured the growth of the brain by MRI in 71 rhesus monkeys who voluntarily consumed alcohol or drink alcohol Scientists accurately measure intake, diet, daily schedule, and health care, eliminating other factors that often lead to observational research results The results help to test previous studies on the effects of alcohol use on human brain development 【3】 Clin Nutri: revealing the potential association between alcohol consumption and mortality doi: 10.1016/j.clnu.2018.05.008 recently, an international journal was published in clinical In the Research Report on nutrition, scientists from the University of Anglia Ruskin clarified the potential relationship between alcohol and population mortality through research The researchers found that drinking a lot of alcohol can lead to the loss of iron absorption in the body, causing pressure on important organs and increasing the risk of death In this paper, 877 women living in sub Saharan Africa were followed up for an average of nine years The results showed that compared with non drinkers, the level of ferritin in drinkers was higher, and ferritin was the blood marker of iron load; iron load occurred when the mechanism of iron regulation was affected by drinking , which will lead to more iron absorbed by the body, and usually lead to a variety of health problems, including heart attack, liver disease and diabetes 【4】 Acer: Alert! Even a small amount of alcohol can increase the risk of death! Doi: 10.1111/acer.13886 recently, in a research report published in the international journal Alcoholism: Clinical & experimental research, researchers from the University of Washington Medical School found that drinking a glass of wine every day for health reasons may not make you as healthy as you think In this paper, researchers analyzed data of more than 400000 people aged 18-85 years and found that compared with people who drank no more than three times a week, individuals who drank more than four times a week (one or two cups at a time) had a 20% increased risk of premature death, and the increased risk of death was the same in all age groups Dr Sarah M Hartz, the first author of the article, said that in the past, we thought that drinking one or two glasses of wine was not a big problem, and even some studies suggested that a small amount of alcohol could help improve the health of the body But now we have found that even the people who drink the least every day have an increased risk of death 【5】 Nature: revealing how drinking can cause DNA damage and increased cancer risk doi: 10.1038/nature25154 in a new study, researchers from MRC Molecular Biology Laboratory of Cambridge University and Sanger Research Institute of welcom foundation confirmed how alcohol can cause stem cells DNA damage in may help explain why drinking alcohol increases the risk of cancer The results are published in the journal Nature Before that, many studies on the exact mechanism of alcohol induced cancer were carried out in cell culture But in this new study, the researchers tested mice to see how alcohol exposure can cause permanent genetic damage The researchers fed mice diluted alcohol (chemically known as ethanol) They then used chromosome analysis and DNA sequencing to study genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol They found that acetaldehyde can break and damage DNA in hematopoietic stem cells, which can lead to chromosome rearrangement of these cells, thus permanently changing their DNA sequence Photo source: http://cn.bing.com [6] arthritis care res: is drinking good for arthritis? This may be a misunderstanding! Doi: 10.1002/acr.23847 several previous studies have shown that moderate drinking is associated with lower risk of serious disease and better quality of life in patients with rheumatoid arthritis, but a recent study published in Arts Care & research, entitled "changes in alcohol use and associations with Disease Activity， Health Status， and Mortality in Rheumatoid Arthritis”。
The study involved 16762 participants, all of whom participated in the study of the national databank for rheumatic diseases The researchers conducted a semi annual survey of patient activity Scale-II (PAS ‐ II) asked them about their drinking and disease status, and then analyzed the factors related to drinking change and the relationship between drinking and disease status and mortality using linear and logical regression model, Cox proportional risk model and boundary structure model 【7】 Nature: drinking and smoking induce driving gene mutations, leading to esophageal cancer doi: 10.1038/s41586-018-0811-x cancer is considered to be composed of heterogeneous tumor cell population, which shows complex hierarchical structure in gene mutation According to recent research, this complete cancer hierarchy itself may be further embedded in a higher level hierarchy generated by multiple rounds of forward selection recursion, and in these multiple rounds of forward selection, obtaining driving gene mutations plays a crucial role Therefore, it is speculated that before the occurrence of cancer, many independent pre cancer clonal cell populations existed in obvious or physiologically normal tissues However, little is known about how these cloned cells transition from the initial stage to the end of life in terms of frequency and size, and how their dynamic changes are affected by environmental and / or genetic factors leading to cancer Major challenges to clarifying these issues include the rarity of such events, the small population of cloned cells, and, more importantly, the difficulty of retrospective analysis of early cloned cells that lead to cancer In a new study, researchers from various research institutions such as Kyoto University in Japan used 682 kinds of micro scale PNE samples (as small as 0.2 mm2) from human subjects with different ages and different life style ESCC risks to study early cloning events in the esophagus, and then used full exome sequencing to detect somatic mutations and The number of copies is abnormal, and the relevant research results are published in the Nature journal 【8】 JCO: attention, drinking friends! Even a glass of wine every day will increase the risk of cancer doi: 10.1200/jco.2017.76.1155 do you like to drink cocktails occasionally? So be careful Recently, researchers found that even moderate drinking can increase the risk of cancer In a research report published in the international journal the Journal of Clinical Oncology, researchers from abroad determined the relationship between drinking and disease through research In the paper, researchers analyzed several studies and found a strong correlation between alcohol consumption and cancer When all the data were collected, the researchers concluded that about 3.5% of all cancer-related deaths were related to alcohol intake In addition, in 2012, researchers found that about 5.5% of new cancer cases and 5.8% of cancer deaths were attributed to alcohol consumption Drinking is the main inducing factor of the overall cancer burden of the population, which is usually not paid enough attention Of course, researchers found that there has been a certain correlation between drinking and cancer risk, which is not related to the specific type of alcohol intake of patients 【9】 The lancet public health: more than 50000 people's Congress data! Drinking reduces life by 20! The biggest risk factor for dementia! Doi: 10.1016/s2468-2667 (18) 30022-7 alcohol is the most important factor to prevent all dementia, especially early-onset dementia This is the result of a nationwide observational study in France published in the lancet public health, where more than one million people have been diagnosed with dementia The study focused specifically on alcohol use, including people who have been diagnosed with mental and behavioral disorders or chronic diseases due to long-term use of alcohol Most of the 57000 patients (older than 65 years) with early dementia (57%) were associated with chronic alcohol abuse The World Health Organization (who) defines chronic alcoholism as drinking more than 60g (pure alcohol) per day for men or 40g for women The study found a strong link between the two, and the authors suggest that screening, alcohol intervention and treatment of alcoholism will effectively reduce the burden of alcohol-induced dementia 【10】 Neuron: alcoholism can lead to the disorder of neural feedback regulation in the brain News Reading: protein links alcohol abuse and changes in brain's reward center previous studies have found that when mice are given alcohol, they will produce similar symptoms to human alcoholism, but how the brain regulates this phenomenon is still unclear before Recently, researchers from UCSF have identified a new type of protein that can regulate alcoholism symptoms by changing the structure of the "feedback" center of the mouse brain This result was published in the latest issue of neuron