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    Home > Medical News > Medical Research Articles > This gel can fight drug-resistant bacteria and induce the body's natural immune defense

    This gel can fight drug-resistant bacteria and induce the body's natural immune defense

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    According to a report in the Journal of the American Chemical Society, researchers from the Royal Institute of Technology, Karolinska Institutet and Karolinska University Hospital said that this new treatment is based on specially developed hydrogels.
    Gum is composed of polymers called dendritic macromolecules

    .

    KTH professor Michael Marko said that the hydrogel is formed spontaneously when sprayed on the wound, and it is 100% degradable and non-toxic
    .
    He said: "Dendrite hydrogels are excellent wound dressing materials because of their soft, adhesive and flexible tactile properties, which can provide ideal skin contact and maintain a moist environment, which is conducive to optimal wound healing

    .
    "

    The antibacterial effect of hydrogels is not yet fully understood, but the key lies in the structure of these macromolecules
    .
    It is characterized by orderly branching, terminated by a large number of positively charged contacts

    .

    "Bacterial cells interact, and so are dendritic macromolecules," he said
    .
    "When they meet, the bacteria will not have good results

    .
    "

    Professor Annelie Brauner of Karolinska Institute said that although it does not contain antibiotics, the hydrogel shows excellent antibacterial properties and is effective against a wide range of clinical bacteria, killing both Gram-positive and Gram-negative bacteria, including from wounds.
    Isolated resistant strains

    .
    This substance can also reduce inflammation

    .

    The hydrogel was tested against several clinically relevant infectious bacteria, including Staphylococcus aureus (S.
    aureus) and P.
    aeruginosa (P.
    aeruginosa)

    .
    The killing effect of hydrogel on Pseudomonas aeruginosa is 100%; the effect of killing Staphylococcus aureus is almost the same

    .

    Cell infection tests show that this gel not only effectively kills clinically resistant bacteria in wounds, but also induces the expression of antimicrobial peptides (or endogenous antibiotics) naturally present in human skin cells
    .

    "These endogenous antibiotics help fight bacteria and clear infections," Brauner said
    .
    "In contrast to traditional antibiotics where bacteria may quickly develop resistance, resistance to antimicrobial peptides is very rare

    .
    "

    Compared with currently available wound dressing hydrogels on the market, hydrogels are even more successful in killing methicillin-resistant Staphylococcus aureus (MRSA)
    .

    The dendrimers that make up the hydrogel are based on polyethylene glycol (PEG) and propionic acid (bis mpa)
    .
    The branches of dendritic polymers are like beautifully pruned apple trees, with many positively charged contact points at their ends, which interact strongly with the negatively charged bacterial cell membrane

    .

    Malkoch said: "Their well-designed branch structure and scalability make them an ideal scaffold for biomedical applications
    .
    "

    Malkoch's laboratory has been using a dendritic-based platform to conduct research on skin infections for more than a year, and the newly published report claims that the synthesis of hydrogels is not so complicated and easy to expand
    .

    Brauner said: "This gel has made an outstanding contribution to fighting multi-drug resistant bacteria, especially in this era when we are running out of available antibiotics
    .
    "

    Journal Reference :

    1. Yanmiao Fan, Soumitra Mohanty, Yuning Zhang, Mads Lü chow, Liguo Qin, Lisa Fortuin, Annelie Brauner, Michael Malkoch.
      Dendritic Hydrogels Induce Immune Modulation in Human Keratinocytes and Effectively Eradicate Bacterial Pathogens .
      Journal of the American Chemical Society , 2021; DOI : 10.
      1021/jacs.
      1c07492


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