Thorac Cancer: ALK positivity is a negative predictor of recurrence-free survival (RFS) in patients with stage I completely resected lung adenocarcinoma

The clinical and prognostic impact of anaplastic lymphoma kinase (ALK) in resected lung cancer is unclear
.
Recently, Thoracic Cancer published a study to evaluate the prognostic and predictive significance of ALK positivity in patients with completely resected lung adenocarcinoma

.

The clinical and prognostic impact of anaplastic lymphoma kinase (ALK) in resected lung cancer is unclear

We retrospectively screened 197 patients with lung adenocarcinoma who underwent complete surgical resection and tested for their ALK status

.

We retrospectively screened 197 patients with lung adenocarcinoma who underwent complete surgical resection and tested for their ALK status

Of the 197 patients, 36 (18%) were ALK positive

.

Of the 197 patients, 36 (18%) were ALK positive

There was no significant difference in OS and RFS rates between the ALK-positive and ALK-negative groups in the total patient cohort (5-year OS: 77.

When confined to pathological stage I patients, there was a significant difference in RFS rates between the ALK-positive and ALK-negative groups (5-year RFS: 55.

9% and 78.

When confined to pathological stage I patients, there was a significant difference in RFS rates between the ALK-positive and ALK-negative groups (5-year RFS: 55.

Multivariate analysis showed that ALK-positive status (hazard ratio [HR] = 3.

431, p = 0.

Multivariate analysis showed that ALK-positive status (hazard ratio [HR] = 3.

High-grade histological subtypes (odds ratio [OR]=5.
988, 95% CI: 2.
083-14.
29, p<0.
001) and never-smokers (OR=4.
292, 95% CI: 1.
280-14.
29, p=0.
018) were significantly found to independently predict ALK-positive status
.
High-grade histological subtypes (odds ratio [OR]=5.
988, 95% CI: 2.
083-14.
29, p<0.
001) and never-smokers (OR=4.
292, 95% CI: 1.
280-14.
29, p=0.
018) were significantly found to independently predict ALK-positive status
.

In conclusion, the study showed that among patients with stage I resected lung adenocarcinoma, ALK-positive patients had worse recurrence-free survival (RFS), and high-grade histological subtypes and never smoking were associated with ALK positivity
.

In conclusion, the study showed that among patients with stage I resected lung adenocarcinoma, ALK-positive patients had worse recurrence-free survival (RFS), and high-grade histological subtypes and never smoking were associated with ALK positivity
.
Studies have shown that among patients with stage I resected lung adenocarcinoma, ALK-positive patients had worse recurrence-free survival (RFS), and high-grade histological subtypes and never smoking were associated with ALK positivity
.
Studies have shown that among patients with stage I resected lung adenocarcinoma, ALK-positive patients had worse recurrence-free survival (RFS), and high-grade histological subtypes and never smoking were associated with ALK positivity
.

 

Original source:

Original source:

Fujibayashi Y, Tane S, Kitazume M, Kuroda S, Kimura K, Kitamura Y, Nishio W.
Resected stage I anaplastic lymphoma kinase-positive lung adenocarcinoma has a negative impact on recurrence-free survival.
Thorac Cancer.
2022 Mar 10.
doi: 10.
1111/1759-7714.
14365.
Epub ahead of print.
PMID: 35274461.

Fujibayashi Y, Tane S, Kitazume M, Kuroda S, Kimura K, Kitamura Y, Nishio W.
Resected stage I anaplastic lymphoma kinase-positive lung adenocarcinoma has a negative impact on recurrence-free survival.
Thorac Cancer.
2022 Mar 10.
doi: 10.
1111/1759-7714.
14365.
Epub ahead of print.
PMID: 35274461.
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