Three cases of the transformation of West Lake University's scientific research achievements: the high output of the School of Life Sciences, the dual implementation of cell therapy and precise diagnosis

2018，，，，、、、、、，，，、。

It is reported that as of 2021, West Lake University will only recruit cutting-edge students with a postgraduate degree or above.

In addition, there is another core laboratory under the School of Life Sciences-Genomics and Bioinformatics Core Laboratory, which mainly uses genomics and bioinformatics methods to promote human understanding of life and diseases, and use information The ability of science and molecular biology to study the problems of life sciences and transform the results.
The laboratory is headed by Dr.
Wang Xi.

In 2019, West Lake University was recognized by the Zhejiang Provincial Department of Science and Technology and established the Zhejiang Provincial Key Laboratory of Growth Regulation and Transformation Research.
The laboratory focuses on "biological size, function, regulation and disease" and relies on the foundation of early organ growth regulation work.
, Use genetics, cell biology, biochemical physical methods, combined with artificial intelligence, clinical medicine, neuropsychology, medicinal chemistry and other interdisciplinary methods to conduct basic theoretical research and translational application research.
The laboratory is headed by Professor Xu Tian.

Key Laboratory of West Lake University

The "School of Science", another college of West Lake University, is dedicated to forward-looking and systematic basic scientific research.
It has departments of mathematics, physics, chemistry, etc.
The research fields cover number theory, analysis, algebra, geometry, condensed matter physics, quantum physics, Atomic and molecular and photophysics, catalytic chemistry, chemical biology, materials chemistry, ultrafast laser spectroscopy, etc.

The Faculty of Science mainly has two platforms: "Public Experiment Platform for Material Science" and "Public Experiment Platform for Molecular Science".
Among them, the material science public experiment platform focuses on the research of quantum, energy, environment, optoelectronic information and other materials and related devices in the frontier fields of material science, supplemented by large-scale shared facilities and equipment and senior professionals, providing overall system characterization analysis technology Support; molecular science public experiment platform is gradually building an in-situ, high-resolution molecular scientific characterization system with various types of spectroscopy, color mass spectrometry, and magnetic resonance spectroscopy as the core technology, aiming at key characterization technical problems in the field of molecular science, and carrying out basic, Research and development of new methods for forward-looking, multi-disciplinary and multi-technical analysis and testing.

The key laboratory under the Faculty of Science-Zhejiang Provincial Key Laboratory of Precision Synthesis of Functional Molecules is headed by Professor Deng Li of West Lake University.
The laboratory aims to achieve biologically active functional molecules through the development of synthetic methodology and synthetic strategy innovations.
The establishment of the library and the synthesis of new functional molecular materials provide source innovation for the development of molecules such as drugs and biomedical functions.

The last major college of West Lake University is the "School of Engineering", which has four academic branches-artificial intelligence, electronic science and technology, environment and resources, materials science and engineering, corresponding to the four future undergraduate and doctoral courses.
Level disciplines: computer science and technology, electronic science and technology, environmental science and engineering, materials science and engineering.

At present, the School of Engineering has established a number of laboratories, covering artificial intelligence, robotics, data science, advanced manufacturing, nanotechnology, new energy, ocean, environment and resource comprehensive utilization, bioengineering, microelectronics and other fields.

In 2019, the College of Engineering was officially approved to establish the Zhejiang Provincial Key Laboratory of 3D Micro-Nano Processing and Characterization.
The laboratory combines the future development direction of microelectronics integration technology and micro-nano processing, and is using the existing planar processing technology to develop micro-nano structures.
At the same time as the device, focus on the research and development of 3D micro-nano processing and characterization technologies, and use these technologies to explore interdisciplinary fields in the research and application of related disciplines, and open up new applications and research directions.
The laboratory is headed by Professor Min Qiu.

In 2021, the College of Engineering was approved by the Zhejiang Provincial Department of Science and Technology to establish the Zhejiang Provincial Key Laboratory of Coastal Environment and Resources Research, dedicated to the study of the coupling mechanism of the coastal land-sea-gas multi-interface and trans-circular layer and its prediction and prediction , In order to better understand the causes of coastal problems and develop new methods, new technologies and new equipment to solve these problems.

West Lake University School of Life Sciences took the lead in completing the transformation of scientific research results

Although it is privately run, the non-profit nature of West Lake University is mainly reflected in contributing research results to society and serving the country and society.
For example, during the national prevention and control of the new crown epidemic in 2020, the Zhou Qiang laboratory of West Lake University used cryo-electron microscopy technology to successfully analyze the full-length structure of the new crown virus receptor ACE2 (Angiotensin-converting enzyme 2).
This is the first analysis of the new coronavirus receptor structure in the world, and it is also an important achievement of West Lake University's emergency work on the prevention and treatment of new coronavirus pneumonia.

Looking back on the past, West Lake University has successively implemented three independent scientific research achievements industrial projects since its establishment, which came from the Gao Xiaofei Laboratory, Guo Tiannan Laboratory of the School of Life Sciences, and Zhou Nanjia Laboratory of the School of Engineering.
The incubation projects correspond to West Lake Biomedicine, West Lake Omi and West Lake Future Intelligent Manufacturing.

Among these three companies, West Lake Biomedicine and West Lake Omi are both incubated by the School of Life Sciences of West Lake University, and both are involved in the medical field.
Among them, West Lake Biomedicine focuses on the popular cell therapy track, West Lake Omi is deeply involved in the AI+ precision medicine field; the last company incubated by the School of Science of West Lake University, West Lake Future Intelligent Manufacturing, focuses on the field of science and technology, and uses 3D printing technology to develop microwave Development of high-precision system equipment such as communications.

Three technology companies incubated by West Lake University

West Lake University's first transformational result: What is red blood cell therapy? Where are the future prospects?

In 2011, Professor Samir Mitragotri, a well-known expert in the field of drug delivery at Harvard University, tried to use red blood cell mimics to deliver target drugs to reach areas of the human body that are difficult to penetrate with traditional drug delivery methods.
This attempt allowed people to see the huge potential of red blood cells as drug carriers-good biocompatibility, high-throughput load, low immunogenicity, safe elimination mechanism, long cycle period, abundant sources, and doughnut shape Red blood cells are extremely flexible and can squeeze through blood vessels smaller than their diameter through blood flow.
Many advantages make red blood cells another good choice for drug carriers.

In addition to the progress in scientific research, in history, the real industrialization of red blood cells as a carrier was in 2014-Rubius Therapeutics was established.
Rubius Therapeutics is a biotechnology company based in Cambridge, England.
The company uses bone marrow stem cells and gene editing technology to transform red blood cells to make them have specific delivery functions.
For example, red blood cells express metabolic enzymes, which are used to treat rare diseases; red blood cells express immune activation signals or tumor-killing substances, which are used for tumor immunotherapy; red blood cells express immune tolerance or neutralizing substances, which are used to treat autoimmunity Sexual disease.

At present, Rubius Therapeutics has made the fastest progress in anti-cancer pipelines.
Three pipelines have completed IND.
On March 15, 2021 local time, the pipeline RTX-240 phase 1/2 clinical trial data was announced.
It is verified that red blood cells can be transformed into clinical drugs to stimulate the human immune system to produce sufficient immune responses.
Rubius' stock price also rose sharply, with a maximum increase of 132%.

Looking back at Xihu Biomedicine's project, the company's focus is on red blood cell therapy, which is also the first company in China to focus on red blood cell therapy.
West Lake Biomedical Technology (Hangzhou) Co.
, Ltd.
(referred to as West Lake Biomedicine) was established in 2019 and is located in Xihu District, Hangzhou.
This is the first industrial transformation project of independent scientific and technological achievements after the establishment of West Lake University, focusing on innovative red blood cell treatment The research and development of the product has successfully created the engineered red blood cell drug technology platform REDx, that is, after obtaining the patient's blood, it is transformed into a large number of engineered red blood cells that can carry drugs outside the body, which can be used to treat various major diseases after being transfused into the human body.

The development of red blood cell drugs is a highly innovative and challenging cutting-edge technology.
Xihu Biomedicine is the first company in China to focus on red blood cell therapy.
Utilizing the natural characteristics and advantages of red blood cells that can load drugs with large flux, good biocompatibility, low immunogenicity, complete biodegradability, and a long-acting cycle of nearly 120 days, the company has developed a treatment for rare diseases.
, Cancer, immunity and metabolism and other fields of innovative treatment options.
At the same time, therapeutic red blood cells have not only been proven to act on antigen-presenting cells to regulate the immune system, but they can also be combined with multiple strategies through the delivery of single or multiple drugs to treat single or multiple diseases, and have alternatives.
The characteristics of strong sex and high safety.

At present, Xihu Biomedicine has established several pipelines of innovative treatments for gout.
The company uses red blood cells to carry urate oxidase into the body to metabolize uric acid, thereby achieving the effect of treating gout.
The West Lake Biomedicine project has started clinical cooperation with Zhejiang Medical Second Hospital.

In addition, West Lake Biopharmaceuticals has completed a pre-A+ round of financing of nearly 100 million yuan in March of this year.
The investors behind it include Chende Capital, Sequoia Capital, and Stow Capital.

In addition to receiving financial support, the West Lake Biomedical team has also received encouragement from the national policy level.
The "14th Five-Year Plan" and the 2035 long-term goal recommendations clearly stated that we should insist on innovation-driven development and comprehensively shape new development advantages.
These include strengthening the national strategic scientific and technological strength, enhancing the technological innovation capabilities of enterprises, stimulating the innovative vitality of talents, and improving the scientific and technological innovation system and mechanism.
Gao Xiaofei said that this is in line with their ideas.
The future research of West Lake Biomedicine is to make a "directed breakthrough" in the treatment of high-incidence diseases on the Chinese disease spectrum and develop targeted innovative drugs.

Future smart manufacturing: 3D printing helps the development of high-precision system equipment such as microwave communication

Another seeded player incubated by West Lake University-"West Lake Future Intelligent Manufacturing" also performed well.

In June 2020, West Lake Future Intelligent Manufacturing (Hangzhou) Technology Development Co.
, Ltd.
(abbreviated as West Lake Future Intelligent Manufacturing) was completed in Hangzhou, China.
This is the second technology company incubated by West Lake University and the first in the domestic electronic 3D printing field.
A three-dimensional precision manufacturing technology company focusing on micron-level precision.

Different from the traditional 3D printing technology, the technology of Xihu Future Intelligent Manufacturing is currently the highest precision electronic 3D printing in China.
It uses new materials as the core to break the limit of 3D printing accuracy.
It designs brand-new 3D printing functional materials, which can achieve hundreds of nanometers.
Micron-level electronic 3D printing is mainly used in high-end systems such as microwave communication, optoelectronic interconnection, and high-precision three-dimensional packaging.

Zhou Nanjia, the founder of Westlake Future Intelligent Manufacturing, once said that the smallest scale 3D printing the company does is to process directly on the chip with 3D printing! By achieving ultra-high precision, Zhou Nanjia’s team introduced 3D multi-material printing technology into the field of chip-level high-end manufacturing, using 3D printing technology for three-dimensional high-precision optoelectronic packaging, manufacturing high-frequency passive components, and relying on the precision and intelligent manufacturing of the School of Engineering of West Lake University.
In the laboratory, 3D printing is applied to meet the high-precision and customized requirements in the field of microelectronics processing.

With the current upgrading of the communications and electronics industry, more and more new demands will emerge in the future.
In the new generation of electronic products, flexible electronics, wearable devices, and embedded miniaturized electronic devices have been difficult to meet with traditional processing methods, while 3D electronic printing has brought a new production method.
Common products such as hearing aids and capsule endoscopes have a high demand for small integrated processing, so 3D printing technology will be more suitable for the production of such small electronic products.

"Xihu Future Intelligent Manufacturing has self-developed 3D printing functional electronic material development and multi-material process integration 3D printing technology, and is in a leading position in the world.
The company's technology has revolutionized the existing high-end manufacturing methods, greatly increased the production rate of high-end components, and broke through China's micro The “stuck neck” problem of the key technology of electronic processing.
” Inno Angel Fund recognized, “The Inno team is very optimistic about the West Lake Future Intelligent Manufacturing team represented by the chief scientist Professor Nanjia Zhou, who has accumulated knowledge in the field of 3D printing technology and material development.
Profound, achieving nanometer-level precision printing, and a wide range of applications, including PCB, three-dimensional circuits, millimeter wave devices, optoelectronic chip packaging and other directions.
"

It is reported that West Lake Future Intelligent Manufacturing has completed tens of millions of yuan in angel round financing, led by Inno Angel Fund, and China Science and Technology Innovation Star is following the investment.
The company is also currently cooperating with listed companies BOE and Shennan Circuit.

Focusing on accurate diagnosis of thyroid, West Lake University's third major achievement transformation and landing

In May 2020, the Guo Tiannan Laboratory of the School of Life Sciences of West Lake University and the Li Ziqing Laboratory of the School of Engineering and a number of clinical collaborators published a paper on MedRxiv.
Using proteome big data and AI methods, they found a group that can help doctors distinguish Protein molecular markers for benign and malignant thyroid nodules are expected to greatly improve the accuracy of judging benign and malignant nodules.

This scientific research result also ushered in a real industrial transformation nine months later-the establishment of Xihu Omi (Hangzhou) Biotechnology Co.
, Ltd.
(abbreviated as Xihu Omi).
The company is committed to combining proteomic big data with artificial intelligence, mass spectrometry-based biological sample digitization technology, and developing new methods of assisted clinical diagnosis based on proteomics and other molecular omics, helping to achieve accurate assisted diagnosis of major human diseases such as tumors.

Clinically, about 60% of thyroid nodules are benign, 10% are malignant, and about 30% of the remaining nodules are difficult to judge whether they are benign or malignant.
The inability to accurately determine the nature of thyroid nodules has led some patients to choose to cut off the thyroid nodules directly after experiencing painful reexaminations.
The cost is that they have to take medicine for life to supplement thyroxine to maintain hormone levels in the body.
However, relevant data disclosed that among patients who have removed thyroid nodules, about 70-80% are benign and do not require medical intervention!

The study of proteomics has given people an opportunity to accurately diagnose thyroid nodules.
Proteomics is a science that studies the protein composition of cells, tissues or organisms and their changing laws with proteome as the research object.
Proteome research can not only provide a material basis for the laws of life activities, but also provide theoretical basis and solutions for the elucidation and conquering of many kinds of disease mechanisms.
Through the comparative analysis of the proteome between normal individuals and pathological individuals, certain "disease-specific protein molecules" can be found to become molecular targets for new drug design or molecular markers for early diagnosis of diseases.

The Guo Tiannan laboratory of the School of Life Sciences of West Lake University compiled 2013 thyroid tissue samples from 1,104 patients with thyroid nodules from 6 clinical hospitals in China and Singapore.
More than 3,700 proteins were discovered and 2622 proteomics data were generated.
Collecting comprehensive data is only the first step, and then accurately "identify" these data-machine learning continuously optimizes the model, and performs approximately 2*1019 operations on 2622 proteomics number input models to find out what can help Doctors identify the 20 key proteins in patients with benign and malignant nodules.
Through a set of complex calculations, a comprehensive score is finally given for the overall situation of the 20 proteins, so as to accurately determine the attributes of the patient's thyroid nodules.
Clinical trials have shown that the comprehensive accuracy rate of this detection method can reach 90%.
Of course, in addition to using research results for precise auxiliary diagnosis, Xihu Omi's scientific research service technology platform will also provide basic research services for disease diagnosis and treatment and drug development.

In March 2020, Xihu Omi announced the completion of tens of millions of yuan in seed round financing, which was jointly led by Chende Capital and Gaorong Capital, with Hillhouse Ventures following the investment.
This round of financing will be mainly used for team expansion, original technology breakthroughs, clinical laboratory landing, research and development cooperation expansion, etc.
, while exploring new applications of technology, but also verifying products on a larger scale.

The head of Gao Rong Capital’s project said: “Gao Rong Capital has long been optimistic about the clinical translation and application of many omics fields, and believes in the huge potential of data from quantitative to qualitative change, and firmly believes that China’s rich local clinical resources will definitely give birth to a world-class China.
Multi-omics company.
Proteomics is a new door opened by humans to explore their own genetic mysteries after genomics and transcriptomics.
The unknowns contained therein may give clinical diagnosis and treatment, drug development, disease prevention, and prognosis management.
Bring new ideas.

The Westlake Omi team has been deeply involved in proteomics for many years, has made innovative achievements in the technical field, solved some underlying technical problems that plagued the industry, and has initially connected the domestic high-quality clinical resource network.
We look forward to the Xihu Omi team will tirelessly continue to search for the peak of proteomics, and at the same time contribute to the development of multi-omics clinical applications in China.
"

About the future: West Lake University has made great achievements in scientific research, but the transformation and landing still need to pass five hurdles and cut six skills

Judging from the three answers that West Lake University has handed in, they have gone through the two stages of "proposing the original concept" and "appearing primary results" in the transformation of medical scientific research results, after which they "possess mature technology" and "achieves primary products.
" Even "reaching market-oriented products" is still a long road.
The process of transformation is full of unknowns and challenges, and any problems in any link may wipe out the previous efforts.

From the current academic achievements of West Lake University, the major laboratories of West Lake University have been specializing in cutting-edge research.
Only in the past 4 months of this year in 2021, West Lake University has successively disclosed 10 academic research results.
From the suppression mechanism of the new coronavirus S protein antibody to revealing the electron microscopy structure of the first human-derived minor spliceosome, West Lake University’s cutting-edge academic achievements have been continuously flowing.
It is worth waiting to see which result will be transformed into the next project to achieve industrialization.
.

Recent academic research results of West Lake University

However, the low conversion rate of China's scientific and technological achievements is still being criticized.
The number of invention patent applications and authorizations in my country ranks first and second in the world, but the results are not optimistic.
The total number of published papers in my country has jumped to the second place in the world, but the conversion rate of science and technology is not high.
The industrialization rate of scientific and technological achievements in developed countries is 25%, while that in my country is only 5%.
The three companies incubated with West Lake University as a representative set an example in the transformation of medical scientific research results.
Although there are many difficulties, the future can be expected.
I believe that with the strong support of the state and society in the future, innovative companies will surely ride the wind and waves in the process of medical incubation, and take the long halberd to overcome the five obstacles and cut the six generals.