Recently, Xiaofeng Gu's team and collaborators from the Institute of Biotechnology, Chinese Academy of Agricultural Sciences published a paper on BMC Biology .
BMC Biology The three-dimensional structure of eukaryotic chromatin plays a vital role in the regulation of gene transcription and the control of various biological processes.
The research takes the japonica rice variety “Nipponbare” and the indica rice variety “93-11” as the research objects, using three-dimensional spatial structure (Hi-C seq), chromatin openness (ATAC seq) and other methods to determine the three-dimensional structure and accessibility of chromatin.
It is worth mentioning that the study found that the genome-wide ATAC signal significantly overlaps with DNA adenine methylation (6mA) modification sites, revealing that changes in chromatin access may be coordinated with DNA 6mA to regulate the response of rice to high temperature stress.
In summary, this study revealed the chromatin response of indica and japonica rice varieties in response to high temperature stress through multi-omics analysis of Hi-C seq, ATAC seq and RNA seq of indica rice "93-11" and japonica rice "Nipponbare" The dynamic change law of three-dimensional structure emphasizes the importance of in-depth study of stress response from the three-dimensional structure of chromatin.
Related paper information: org/10.
org/10.
1186/s12915-021-00996-4" target="_blank">https://doi.
org/10.
1186/s12915-021-00996-4
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