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    Home > Active Ingredient News > Infection > Three domestic cases of Delta variants: What is the difference between vaccination and non-vaccination?

    Three domestic cases of Delta variants: What is the difference between vaccination and non-vaccination?

    • Last Update: 2021-06-22
    • Source: Internet
    • Author: User
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    The protection rate of the new crown vaccine is not 100%.
    What is the difference between the vaccinated person and the unvaccinated person after being infected with the new crown virus after vaccination? The latest paper published by China Disease Control revealed that three confirmed cases were infected with the mutant new coronavirus.
    Two of them had been vaccinated against the new coronavirus and one was not.
    The time for them to produce antibodies after being infected with the new crown, the cycle threshold of PCR, and the length of hospital stay were all present.
    Significant difference
    .

    The above-mentioned papers were published in the Weekly Report of the China Centers for Disease Control and Prevention published on June 12
    .

    The authors of the paper are from the Chengdu Emerging Infectious Disease Prevention and Control Workstation of the Chinese Academy of Medical Sciences and the Chengdu Center for Disease Control and Prevention
    .

    Epidemiological investigations revealed that Case A returned to Chengdu from India via Kathmandu, the capital of Nepal, on April 26 and tested positive for the new crown virus at Chengdu Customs
    .

    On May 2, Case B, who was on the same flight as Case A, was tested positive for COVID-19 during isolation
    .

    On May 9, the case C of another flight was diagnosed during isolation
    .
    C had been working in Kathmandu before returning home .

    The three of them had a negative nucleic acid test (PCR) and COVID-19 antibody test before boarding the plane
    .

    The three confirmed cases of new crowns A, B, and C were transferred to the Chengdu Public Health Clinical Center for isolation treatment on April 26, May 3, and May 10, 2021, respectively
    .

    Among the three, Case A has received two doses of the inactivated Covid-19 vaccine (Beijing Institute of Biological Products), the first dose on January 25, and the second dose on February 8
    .

    Case C was vaccinated on October 19 and November 4, 2020 (Kexing)
    .

    But case B was not vaccinated
    .

    The above paper pointed out that shortly after admission of the three patients, the chest (CT) showed abnormalities and increased lung lesions
    .

    During the isolation treatment period, there are three differences between vaccinated and unvaccinated patients: First, the IgG, IgM, and total antibodies of the three people were tested.
    Case A turned positive on the 4th day of diagnosis, and case C was diagnosed It turned positive on the first day, and the antibody titer was very high
    .

    However, the unvaccinated case B had negative antibodies on the 7th day of diagnosis, (case B remained negative for IgM during the entire hospitalization period, until the 13th day IgG and total antibodies were positive and the titer was low), which indicates that the vaccinated cases have changed from The time to be diagnosed as positive for antibodies is shorter than for unvaccinated cases
    .

    The second difference is that the cycle threshold (Ct) value of fluorescent PCR in samples of unvaccinated patients is lower than that of vaccinated patients
    .

    In the controlled trial of the new crown vaccine, there was a similar finding that on days 12-37 after vaccination, the Ct value of vaccinated individuals was significantly higher than that of the unvaccinated control group
    .

    The third difference is reflected in the length of hospital stay
    .

    The above paper points out that the hospital stay of vaccinated patients is shorter than that of unvaccinated patients
    .

    Case A and case C were discharged after 21 and 25 days of hospitalization, respectively, and case B was discharged on June 7 after 36 days
    .

    The above paper pointed out that through genetic sequencing of the three nasopharyngeal swab samples, it was found that the strain they were infected with was B.
    1.
    617.
    2.
    Since December 2020, the mutant strain has been circulating in India and has been recognized by the World Health Organization.
    Designated as one of the variants of concern (VOC) strains
    .

    The paper pointed out that the mutant new crown virus poses a great threat to China's new crown prevention and control
    .

    There is an urgent need to further study the epidemiological impact of mutant viruses and the effects of vaccines
    .

    As there are still local outbreaks of new crown epidemics in Anhui, Liaoning, and Guangdong, vaccination should be the first strategy and effectively promote the disease control of new crown pneumonia
    .

    On June 11, at the press conference of the Joint Prevention and Control Mechanism of the State Council, Feng Zijian, a researcher at the China Centers for Disease Control and Prevention, also said that in the case of the Guangdong epidemic, people who had not been vaccinated among the confirmed cases became severely ill or had severe illness.
    The proportion is significantly higher than that of the vaccinated people, indicating that there is still a protective effect on the mutant strains after vaccination
    .

    Paper link: http://weekly.
    chinacdc.
    cn/en/article/doi/10.
    46234/ccdcw2021.
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