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Science and Technology Daily News,
Tianjin
University Professor Chen Haixia's natural medicine
chemistry
team from China's traditional
cuisine
"La Bacillus" for the first time found three new active peptides, these active peptides have significant antibacterial properties, is expected to become
antibiotics
substitute. The results have been published as a cover article
International
Food And Food Function.
the discovery and application of antibiotics is a revolution in the history of human medicine. However, with the widespread clinical use, there is a situation of abuse and misuse of antibiotics in many countries. Drug abuse makes bacteria quickly adapt to the antibiotic environment, a variety of "superbugs" have been born, seriously endangering people's health. Finding safe and effective alternatives to antibiotics is one of the effective ways to solve the global medical problem of "bacterial resistance".
active peptides are called "chemical messengers" in plants and animals and regulate life processes such as body growth, development, reproduction, metabolism and behavior. Professor Chen Haixia's team has long focused on the health and therapeutic effects of various functional components in food. This time, they found and identified 3 kinds of new active peptides in the traditional Chinese food", and made an in-depth study of their antibacterial activity and mechanism of action. The research shows that when these active peptides act on bacteria, they can form pores on the surface of bacterial cells by using the mechanism of "barrel hole model" and "carpet model", which destroys bacterial cell membranes and causes the leakage of cell contents, thus achieving the goal of antibacterial control.
"the wide range of biological activity of the new active peptide shows its promising medical application." Professor Chen Haixia's team of Dr. Gao Xudong introduced that the new active peptides not only have good antibacterial activity, and have low toxicity, not easy to produce drug-resistant bacteria characteristics, is expected to become a safe and effective antibiotic substitute suitable for human body, the relevant research results for the further development and application of natural antimicrobial peptide drugs provide a theoretical basis. At present, the research is supported by the National Natural Science Foundation of China, Tianjin Science and Technology Fund and many other funds. Chen Yujiao Defang.